Introduction:
A recent pilot study conducted in São Paulo, Brazil, has revealed a potential game-changer in treating chronic diabetic foot ulcers. Researchers from the Federal University of Juiz de Fora (UFJF) explored the use of Progressive PRF (PRO-PRF), a third-generation platelet-rich fibrin matrix, for its ability to accelerate wound healing. This innovative treatment offers hope for individuals suffering from complex diabetic ulcers.
A Step Towards Recovery
The pilot study enrolled three male patients with type 2 diabetes experiencing chronic ulcers on their lower limbs. Following a carefully designed protocol, including lesion preparation, PRO-PRF application, and lesion protection, the patients, aged 51-57 years, underwent PRO-PRF treatment from May to August 2022.
Revolutionary PRO-PRF Membranes
The PRO-PRF developed by the UFJF oral and maxillofacial surgery team introduced a breakthrough with its three-dimensional membrane adaptable to each patient’s needs. Within the first session, the average lesion area reduced by 36.6%, with further progress observed in subsequent weeks. Remarkably, all patients achieved complete ulcer healing within an average of 9 weeks.
Positive Impact: Efficacy and Affordability:
Apart from its remarkable efficacy, the PRO-PRF treatment also offers economic benefits, potentially benefiting a larger population through the Brazilian public health system.
Future Prospects and Ongoing Research:
Building upon the success of this pilot study, the research group is now pursuing further investigations, offering a more comprehensive analysis of PRO-PRF’s potential. They are designing a randomized study to compare the efficacy of third-generation PRF with standard dressings, signifying the promise and potential impact of PRO-PRF in wound healing.
Simple, Reproducible, and Affordable:
The PRO-PRF matrices used in the study were developed in a laboratory setting, utilizing blood samples obtained through venous puncture. The process involves centrifugation to obtain a concentrate in a liquid phase, which is then transformed into a membrane. Both forms of PRO-PRF can be applied immediately, thanks to a straightforward and cost-effective procedure.
Conclusion:
The pilot study conducted in São Paulo, Brazil, has demonstrated the potential of PRO-PRF as an effective and affordable solution for treating chronic diabetic foot ulcers. The remarkable results achieved in terms of accelerated wound healing and complete lesion closure within an average of 9 weeks offer hope for individuals living with complex diabetic ulcers. Ongoing research will continue to explore the possibilities and impact of PRO-PRF, opening new avenues for more effective wound-healing strategies.
Dear doctors, how can PRO-PRF be further optimized to address challenges associated with diabetic foot ulcers, such as infection and recurrence?
Reference
- Saboia-Dantas CJ, Dechichi P, Fech RL, de Carvalho Furst RV, Raimundo RD, Correa JA. Progressive Platelet Rich Fibrin tissue regeneration matrix: Description of a novel, low cost and effective method for the treatment of chronic diabetic ulcers—Pilot study. Plos one. 2023 May 4;18(5):e0284701.
