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Osteogenesis Imperfecta Type VIII: A Call for Genetic Testing and Early Intervention

Introduction Osteogenesis imperfecta (OI) type VIII is a rare autosomal-recessive disorder characterized by white sclerae, severe growth deficiency, extreme skeletal under-mineralization, and bulbous metaphysis.1 Despite its prevalence of approximately 1 in 10,000–20,000 births, genetic testing for confirmation is often overlooked, and the diagnosis relies solely on clinical features.2 The reported case emphasizes the need for increased genetic testing to …

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Managing Systemic Cancer Therapy in Older Patients: Practical ASCO Guideline Update

The latest update of the American Society of Clinical Oncology (ASCO) guideline aims to revise and enhance the 2018 guideline on assessing and managing vulnerabilities in older cancer patients undergoing chemotherapy. It was prompted by two significant clinical trials, GAP701 and GAIN, which explored the integration of geriatric assessment (GA) and GA-guided management (GAM) to reduce chemotherapy-related toxic effects in older adults with cancer. The update …

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Successful Double Lung Transplant Technique: Hope for Late-Stage Cancer Patients

Introduction Late-Stage Lung Cancer can be a devastating diagnosis, and patients are left with limited choices for treatment and a desolate prognosis. In recent years, medical advancements have brought new hope to these patients by successfully performing a Double Lung Transplant Procedure. This groundbreaking procedure offers a ray of hope to late-stage lung cancer patients, providing them …

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Breaking Barriers: Fontan Procedure’s Impact on Pediatric Hypoplastic Left Heart Syndrome

Introduction Pediatric Hypoplastic Left Heart Syndrome (HLHS) is a rare and severe Congenital Heart Defect (CHD) that poses a significant challenge to the medical community. In the past, HLHS was believed to be a life-threatening diagnosis with limited treatment choices and a dismal prognosis. However, introducing the Fontan Procedure has brought about a revolutionary change in managing this complex condition, offering …

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ASMBS Guidelines for General Surgeons: Bariatric Emergency Management

Metabolic and bariatric surgeries (MBS) have become a prevalent global practice for effectively treating obesity and metabolic diseases. The rising demand for MBS due to the worldwide obesity epidemic has increased the incidence of post-surgical emergencies. The most common MBS procedures are Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), known for their minimally invasive approach and reduced mortality. However, the growing number of …

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WHO Updates Essential Medicines List (2023): Obesity Drugs Removed; Ebola and MS Drugs Added

Introduction The World Health Organization (WHO) has just updated its 23rd Essential Medicines List. This list includes medicines that are really important for good healthcare. It now has some new medicines for diseases like Ebola and multiple sclerosis. But the current list doesn’t include medicines for obesity. What are Essential Medicines? Essential medicines are those …

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The Future of Uterus Transplantation: Innovating Motherhood

Introduction Absolute Uterine Factor Infertility (AUFI) is a type of fertility disorder where the absence or dysfunction of the uterus makes conception and maintaining a pregnancy impossible. This condition impacts approximately 1 in 500 women of reproductive age and accounts for around 8% of infertility cases in couples. Women experiencing AUFI due to congenital conditions such …

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Radiation Revitalized: The Promise of Nuclear Medicine Therapy

IntroductionIn medicine, progress is an unstoppable force that continually uncovers new ways to diagnose, treat, and ultimately overcome diseases. Nuclear Medicine Therapy stands out as an exceptional innovation among these advancements. Combining precise targeting methods and the power of radiation, it introduces a new level of therapeutic potential. This modern approach could revolutionize how we address various …

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Intravascular Lymphoma Presenting with Hot Lung Sign

Introduction Intravascular large B-cell lymphoma (IVLBCL) represents an uncommon variant of extranodal non-Hodgkin lymphoma (NHL) with malignancy originating from B-cells and challenging-to-diagnose condition due to its scarcity, nonspecific symptoms, and rapid progression.1,2 A case presents a male patient in his early 70s who exhibited the intriguing “hot lung sign” on 18F-fluorodeoxyglucose positron emission tomography (PET) CT, leading to the diagnosis of IVCL.3 Case Presentation3 Figure …

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Clinical Practice Guideline for the Management of Posttraumatic Stress Disorder (PTSD) and Acute Stress Disorder

Introduction The Clinical Practice guideline by the Department of Veterans Affairs (VA) and the US Department of Defense (DoD) offers evidence-based recommendations for assessing, diagnosing, preventing, and treating Posttraumatic Stress Disorder (PTSD) and Acute Stress Disorder. The guideline is a valuable resource for healthcare professionals, aiming to enhance the quality of care provided to individuals affected by these disorders.1 Recommendations1 …

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