{"id":35499,"date":"2024-05-30T15:53:44","date_gmt":"2024-05-30T07:53:44","guid":{"rendered":"https:\/\/docquity.com\/?post_type=articles&p=35499"},"modified":"2025-02-11T13:40:25","modified_gmt":"2025-02-11T05:40:25","slug":"thuoc-giam-can-xua-va-nay","status":"publish","type":"articles","link":"https:\/\/docquity.com\/vi\/articles\/thuoc-giam-can-xua-va-nay\/","title":{"rendered":"Thu\u1ed1c gi\u1ea3m c\u00e2n: X\u01b0a v\u00e0 nay"},"content":{"rendered":"\n

B\u00e9o ph\u00ec (BMI \u2265 30 kg\/m2<\/sup>) l\u00e0 b\u1ec7nh l\u00fd c\u00f3 t\u1ef7 l\u1ec7 m\u1eafc t\u0103ng \u0111\u00e1ng k\u1ec3 trong th\u1eadp k\u1ef7 v\u1eeba qua. M\u1eb7c d\u00f9 BMI kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t ch\u1ec9 s\u1ed1 \u0111o l\u01b0\u1eddng ho\u00e0n h\u1ea3o \u0111\u1ec3 ph\u1ea3n \u00e1nh t\u00ecnh tr\u1ea1ng b\u00e9o ph\u00ec, tuy nhi\u00ean BMI \u2265 30 c\u00f3 li\u00ean quan \u0111\u1ebfn g\u00e1nh n\u1eb7ng b\u1ec7nh t\u1eadt v\u00e0 t\u1ef7 l\u1ec7 t\u1eed vong t\u0103ng. C\u1ee5 th\u1ec3, BMI \u2265 30 c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c t\u0103ng t\u1ef7 l\u1ec7 bi\u1ebfn ch\u1ee9ng c\u1ee7a m\u1ed9t s\u1ed1 b\u1ec7nh l\u00fd nh\u01b0 \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2, t\u0103ng huy\u1ebft \u00e1p, ng\u01b0ng th\u1edf t\u1eafc ngh\u1ebdn khi ng\u1ee7 v\u00e0 b\u1ec7nh kh\u1edbp tho\u00e1i h\u00f3a. Hi\u1ec7n nay, c\u00f3 m\u1ed9t s\u1ed1 nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb m\u1edbi \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n, nhi\u1ec1u h\u01b0\u1edbng d\u1eabn \u0111i\u1ec1u tr\u1ecb c\u0169ng bao g\u1ed3m c\u00e1c thu\u1ed1c n\u00e0y trong c\u00e1c khuy\u1ebfn c\u00e1o \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec [1].<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

H\u00ecnh 1.<\/strong> Ch\u1eb7ng \u0111\u01b0\u1eddng ph\u00e1t tri\u1ec3n c\u1ee7a thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec<\/p>\n\n\n\n

B\u00e0i vi\u1ebft cung c\u1ea5p t\u1ed5ng quan v\u1ec1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec, c\u00e1c b\u1eb1ng ch\u1ee9ng li\u00ean quan \u0111\u1ebfn hi\u1ec7u l\u1ef1c v\u00e0 t\u00ednh an to\u00e0n v\u00e0 c\u00e1c h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec hi\u1ec7n c\u00f3 \u0111\u1ec3 h\u1ed7 tr\u1ee3 qu\u00fd v\u1ecb \u0111\u1ed3ng nghi\u1ec7p trong vi\u1ec7c l\u1ef1a ch\u1ecdn thu\u1ed1c v\u00e0 \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n

B\u1ea3ng 1. <\/strong>C\u00e2n nh\u1eafc khi k\u00ea \u0111\u01a1n thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

C\u00c1C THU\u1ed0C \u0110I\u1ec0U TR\u1eca B\u00c9O PH\u00cc \u0110\u01af\u1ee2C FDA CH\u1ea4P THU\u1eacN<\/strong><\/h2>\n\n\n\n

Do s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 qu\u00e1 tr\u00ecnh \u0111\u0103ng k\u00fd, ch\u1ea5p thu\u1eadn thu\u1ed1c gi\u1eefa c\u00e1c qu\u1ed1c gia, c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng c\u0169ng s\u1ebd kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c qu\u1ed1c gia. B\u00e0i vi\u1ebft ch\u1ec9 \u0111\u1ec1 c\u1eadp \u0111\u1ebfn c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn. T\u1ed5ng quan v\u1ec1 t\u00ednh an to\u00e0n, hi\u1ec7u l\u1ef1c, gi\u00e1 c\u1ea3 v\u00e0 m\u1ed9t s\u1ed1 c\u00e2n nh\u1eafc khi th\u1ef1c h\u00e0nh c\u1ee7a m\u1ed9t s\u1ed1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111\u01b0\u1ee3c \u0111\u1ec1 c\u1eadp b\u00ean d\u01b0\u1edbi. Theo th\u1eddi gian, s\u1ef1 hi\u1ec3u bi\u1ebft v\u1ec1 sinh b\u1ec7nh h\u1ecdc c\u1ee7a b\u00e9o ph\u00ec t\u0103ng cho ph\u00e9p nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec v\u1edbi hi\u1ec7u l\u1ef1c cao h\u01a1n. Tuy nhi\u00ean, kh\u00f4ng h\u1eb3n thu\u1ed1c m\u1edbi s\u1ebd cho hi\u1ec7u l\u1ef1c \u0111i\u1ec1u tr\u1ecb cao h\u01a1n thu\u1ed1c c\u0169, do v\u1eady, c\u1ea7n ph\u1ea3i quan s\u00e1t \u0111\u00e1p \u1ee9ng c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n ri\u00eang l\u1ebb v\u1edbi thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec [1].<\/p>\n\n\n\n

Giai \u0111o\u1ea1n tr\u01b0\u1edbc n\u0103m 1999<\/strong><\/p>\n\n\n\n

S\u1ed1 l\u01b0\u1ee3ng thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn tr\u01b0\u1edbc n\u0103m 1999 m\u00e0 v\u1eabn l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng ng\u00e0y nay kh\u00f4ng c\u00f3 nhi\u1ec1u. Hi\u1ec7n nay ch\u1ec9 c\u00f3 phentermine v\u00e0 c\u00e1c amine giao c\u1ea3m kh\u00e1c nh\u01b0 phendimetrazine. Phentermine l\u00e0 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n nhi\u1ec1u nh\u1ea5t \u1edf Hoa K\u1ef3 do gi\u00e1 c\u1ea3 th\u1ea5p. Tuy nhi\u00ean, v\u1eabn ch\u01b0a c\u00f3 d\u1eef li\u1ec7u so s\u00e1nh \u0111\u1ed1i \u0111\u1ea7u hi\u1ec7u l\u1ef1c gi\u1ea3m c\u00e2n c\u1ee7a phentermine v\u1edbi c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec m\u1edbi h\u01a1n. Kh\u00e1c v\u1edbi c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec kh\u00e1c, phentermine ch\u1ec9 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn cho 3 th\u00e1ng s\u1eed d\u1ee5ng, m\u1eb7c d\u00f9 c\u00e1c h\u01b0\u1edbng d\u1eabn \u0111i\u1ec1u tr\u1ecb hi\u1ec7n nay \u0111\u1ec3 khuy\u1ebfn c\u00e1o k\u00ea \u0111\u01a1n trong th\u1eddi gian d\u00e0i h\u01a1n [1].<\/p>\n\n\n\n

Phentermine<\/em><\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Giai \u0111o\u1ea1n 1999 \u2013 2014<\/em><\/strong><\/p>\n\n\n\n

Nhi\u1ec1u thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec v\u1edbi c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng kh\u00e1c nhau \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn trong giai \u0111o\u1ea1n n\u00e0y, ph\u1ea3n \u00e1nh th\u1eddi k\u1ef3 ph\u00e1t tri\u1ec3n v\u01b0\u1ee3t tr\u1ed9i v\u1ec1 s\u1ef1 hi\u1ec3u bi\u1ebft c\u1ee7a y khoa v\u1ec1 b\u1ec7nh b\u00e9o ph\u00ec. C\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn trong giai \u0111o\u1ea1n n\u00e0y bao g\u1ed3m orlistat, l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf h\u1ea5p thu ch\u1ea5t b\u00e9o trong b\u1eefa \u0103n \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn n\u0103m 1999, ph\u1ed1i h\u1ee3p phentermine v\u00e0 topiramate, ph\u1ed1i h\u1ee3p naltrexone v\u00e0 bupropion v\u00e0 ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP \u2013 1 liraglutide. C\u00e1c thu\u1ed1c n\u00e0y mang \u0111\u1ebfn hi\u1ec7u l\u1ef1c gi\u1ea3m c\u00e2n kh\u00e1c nhau, t\u1eeb 3 \u2013 11%, ph\u1ee5 thu\u1ed9c li\u1ec1u v\u00e0 th\u1eddi gian s\u1eed d\u1ee5ng. \u0110\u1ed1i v\u1edbi c\u00e1c thu\u1ed1c d\u1ea1ng ph\u1ed1i h\u1ee3p, phentermine v\u00e0 topiramate n\u1ebfu \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u01a1n l\u1ebb c\u0169ng mang \u0111\u1ebfn hi\u1ec7u qu\u1ea3 gi\u1ea3m c\u00e2n [1].<\/p>\n\n\n\n

Orlistat<\/em><\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Phentermine \u2013 topiramate ph\u00f3ng th\u00edch k\u00e9o d\u00e0i<\/em><\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Naltrexone \u2013 bupropion ph\u00f3ng th\u00edch duy tr\u00ec<\/em><\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Liraglutide<\/em><\/strong><\/p>\n\n\n\n

Giai \u0111o\u1ea1n 2015 \u2013 nay<\/strong><\/p>\n\n\n\n

Nhi\u1ec1u thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec v\u1edbi hi\u1ec7u l\u1ef1c cao \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn trong v\u00e0i n\u0103m qua (c\u00e2n n\u1eb7ng trung b\u00ecnh gi\u1ea3m 11 \u2013 21%). C\u00e1c thu\u1ed1c n\u00e0y ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi \u0111\u01b0\u1eddng ti\u00eam d\u01b0\u1edbi da. C\u00e1c thu\u1ed1c n\u00e0y c\u00f3 gi\u00e1 cao h\u01a1n c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec c\u0169 h\u01a1n [1].<\/p>\n\n\n\n

Semaglutide<\/em><\/strong><\/p>\n\n\n\n

Tirzepatide<\/em><\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec cho c\u00e1c h\u1ed9i ch\u1ee9ng di truy\u1ec1n g\u00e2y b\u00e9o ph\u00ec<\/strong><\/p>\n\n\n\n

Ch\u1ec9 c\u00f3 duy nh\u1ea5t setmelatonide l\u00e0 thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn hi\u1ec7n nay. Setmelatonide kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn cho ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec n\u00f3i chung, nh\u01b0ng ch\u1ec9 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn cho c\u00e1c b\u1ec7nh l\u00fd di truy\u1ec1n \u0111\u01a1n gen v\u00e0 h\u1ed9i ch\u1ee9ng b\u00e9o ph\u00ec [1].<\/p>\n\n\n\n

Setmelanotide<\/em><\/strong><\/p>\n\n\n\n

C\u00e1c thu\u1ed1c c\u00f3 ch\u1ec9 \u0111\u1ecbnh gi\u1ea3m c\u00e2n off-label<\/strong><\/p>\n\n\n\n

Nhi\u1ec1u thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ch\u01b0a \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn cho ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec, tuy nhi\u00ean c\u00e1c thu\u1ed1c n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t t\u00e1c \u0111\u1ed9ng gi\u1ea3m c\u00e2n \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. C\u00e1c thu\u1ed1c n\u00e0y bao g\u1ed3m metformin, ch\u1ea5t \u1ee9c ch\u1ebf k\u00eanh \u0111\u1ed3ng v\u1eadn chuy\u1ec3n natri-glucose 2 (SGLT2i), lisdexamfetamine, bupropion, topiramte. Metformin l\u00e0 t\u00e1c nh\u00e2n thu\u1ed9c nh\u00f3m biguanide, l\u00e0 l\u1ef1a ch\u1ecdn \u0111\u1ea7u tay cho h\u1ea7u h\u1ebft b\u1ec7nh nh\u00e2n m\u1eafc \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2. Metformin c\u00f3 th\u1ec3 gi\u1ea3m c\u00e2n nh\u1eb9 (2.5% so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c). C\u00e1c thu\u1ed1c thu\u1ed9c nh\u00f3m SGLT2i \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn cho b\u1ec7nh nh\u00e2n m\u1eafc \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2, suy tim v\u00e0 b\u1ec7nh th\u1eadn m\u1ea1n. \u1ede b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2, SGLT2i c\u00f3 th\u1ec3 gi\u1ea3m li\u1ec1u insulin \u2013 m\u1ed9t y\u1ebfu t\u1ed1 \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0m t\u0103ng c\u00e2n. Lisdexamfetamine l\u00e0 d\u1eabn xu\u1ea5t c\u1ee7a amphetamine, \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n t\u0103ng u\u1ed1ng v\u00e0 r\u1ed1i lo\u1ea1n t\u0103ng \u0111\u1ed9ng \u2013 gi\u1ea3m ch\u00fa \u00fd. Lisdexamfetamine c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn cho b\u1ec7nh nh\u00e2n b\u00e9o ph\u00ec b\u1ecb r\u1ed1i lo\u1ea1n \u0103n u\u1ed1ng [1].<\/p>\n\n\n\n

H\u01af\u1edaNG D\u1eaaN \u0110I\u1ec0U TR\u1eca B\u00c9O PH\u00cc<\/strong><\/h2>\n\n\n\n

Trong th\u1eadp k\u1ef7 v\u1eeba qua, nhi\u1ec1u hi\u1ec7p h\u1ed9i y khoa \u0111\u00e3 \u0111\u01b0a ra h\u01b0\u1edbng d\u1eabn \u0111i\u1ec1u tr\u1ecb ki\u1ec3m so\u00e1t b\u00e9o ph\u00ec c\u00f3 s\u1eed d\u1ee5ng thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec. V\u00e0o n\u0103m 2013, Hi\u1ec7p h\u1ed9i B\u00e9o ph\u00ec, Hi\u1ec7p h\u1ed9i Tim m\u1ea1ch Hoa K\u1ef3 v\u00e0 Vi\u1ec7n Tim m\u1ea1ch Hoa K\u1ef3 \u0111\u00e3 c\u00f4ng b\u1ed1 h\u01b0\u1edbng d\u1eabn ki\u1ec3m so\u00e1t b\u00e9o ph\u00ec [2]. H\u01b0\u1edbng d\u1eabn n\u00e0y c\u00f3 \u0111\u1ec1 c\u1eadp \u0111\u1ebfn vi\u1ec7c c\u00e2n nh\u1eafc b\u1eaft \u0111\u1ea7u s\u1eed d\u1ee5ng thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec cho b\u1ec7nh nh\u00e2n c\u00f3 BMI \u2265 30 ho\u1eb7c \u2265 27 c\u00f3 b\u1ec7nh m\u1eafc k\u00e8m li\u00ean quan \u0111\u1ebfn c\u00e2n n\u1eb7ng m\u00e0 kh\u00f4ng th\u1ec3 gi\u1ea3m c\u00e2n ch\u1ec9 b\u1eb1ng thay \u0111\u1ed5i l\u1ed1i s\u1ed1ng. V\u00e0o n\u0103m 2015, sau khi FDA ch\u1ea5p thu\u1eadn thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec m\u1edbi, Hi\u1ec7p h\u1ed9i B\u1ec7nh N\u1ed9i ti\u1ebft \u0111\u00e3 c\u00f4ng b\u1ed1 h\u01b0\u1edbng d\u1eabn \u0111i\u1ec1u tri b\u00e9o ph\u00ec v\u1edbi khuy\u1ebfn c\u00e1o t\u01b0\u01a1ng t\u1ef1, nh\u01b0ng \u0111\u1ed3ng th\u1eddi b\u1ed5 sung th\u00eam khuy\u1ebfn c\u00e1o duy tr\u00ec thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec trong giai \u0111o\u1ea1n duy tr\u00ec gi\u1ea3m c\u00e2n v\u00e0 \u0111\u1ec1 xu\u1ea5t chi\u1ebfn l\u01b0\u1ee3c theo d\u00f5i b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c gi\u1ea3m c\u00e2n [3]. Hi\u1ec7p h\u1ed9i N\u1ed9i ti\u1ebft khuy\u1ebfn c\u00e1o ch\u1ed1ng k\u00ea \u0111\u01a1n c\u00e1c thu\u1ed1c gi\u1ea3m c\u00e2n off-label n\u1ebfu ch\u1ec9 \u0111\u1ec3 gi\u1ea3m c\u00e2n. Hi\u1ec7p h\u1ed9i N\u1ed9i ti\u1ebft c\u1eadp nh\u1eadt khuy\u1ebfn c\u00e1o m\u1edbi, c\u00e2n nh\u1eafc s\u1eed d\u1ee5ng thu\u1ed1c gi\u1ea3m c\u00e2n off-label, phentermine trong th\u1eddi gian > 3 th\u00e1ng \u0111\u1ec3 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 dung n\u1ea1p. M\u1edbi \u0111\u00e2y nh\u1ea5t, v\u00e0o n\u0103m 2022, Hi\u1ec7p h\u1ed9i Ti\u00eau hoa Hoa K\u1ef3 (ACG) \u0111\u00e3 c\u00f4ng b\u1ed1 h\u01b0\u1edbng d\u1eabn ki\u1ec3m so\u00e1t b\u00e9o ph\u00ec [4]. ACG khuy\u1ebfn c\u00e1o semaglutide li\u1ec1u 2.4 cho b\u1ec7nh nh\u00e2n b\u00e9o ph\u00ec d\u1ef1a tr\u00ean c\u00e1c b\u1eb1ng ch\u1ee9ng m\u1ea1nh m\u1ebd c\u1ee7a semaglutide. C\u00e1ch ti\u1ebfp c\u1eadn k\u00ea \u0111\u01a1n thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n trong h\u00ecnh 2.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

H\u00ecnh 2.<\/strong> Ti\u1ebfp c\u1eadn k\u00ea \u0111\u01a1n thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec<\/p>\n\n\n\n

B\u00c0N LU\u1eacN<\/strong><\/h2>\n\n\n\n

Semaglutide v\u00e0 tirzepatide l\u00e0 d\u1ea5u hi\u1ec7u cho th\u1ea5y nh\u1eefng h\u1ee9a h\u1eb9n c\u1ee7a l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec. M\u1edf ra hy v\u1ecdng c\u00f3 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec v\u1edbi hi\u1ec7u l\u1ef1c gi\u1ea3m c\u00e2n t\u01b0\u01a1ng \u0111\u01b0\u01a1ng ph\u1eabu thu\u1eadt. V\u1edbi s\u1ef1 canh tranh gi\u1eefa c\u00e1c s\u1ea3n ph\u1ea9m, gi\u00e1 c\u1ea3 c\u1ee7a c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec c\u00f3 th\u1ec3 gi\u1ea3m trong t\u01b0\u01a1ng lai.<\/p>\n\n\n\n

\n\n\n\n

T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/h3>\n\n\n\n
    \n
  1. Henderson K, Lewis, Sloan CE, Bessesen DH, Arterburn D. Effectiveness and safety of drugs for obesity. BMJ. 2024 Mar 25;384:e072686. doi: 10.1136\/bmj-2022-072686.<\/li>\n\n\n\n
  2. Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA\/ACC\/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation 2014;129:S102-38. 01.cir.0000437739.71477.ee<\/li>\n\n\n\n
  3. Apovian CM, Aronne LJ, Bessesen DH, et al, Endocrine Society. Pharmacological management of obesity: an endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2015;100:342- 62. doi:10.1210\/jc.2014-3415<\/li>\n\n\n\n
  4. Grunvald E, Shah R, Hernaez R, et al, AGA Clinical Guidelines Committee. AGA clinical practice guideline on pharmacological interventions for adults with obesity. Gastroenterology 2022;163:1198-225. doi:10.1053\/j. gastro.2022.08.045<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    B\u00e9o ph\u00ec (BMI \u2265 30 kg\/m2) l\u00e0 b\u1ec7nh l\u00fd c\u00f3 t\u1ef7 l\u1ec7 m\u1eafc t\u0103ng \u0111\u00e1ng k\u1ec3 trong th\u1eadp k\u1ef7 v\u1eeba qua. M\u1eb7c d\u00f9 BMI kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t ch\u1ec9 s\u1ed1 \u0111o l\u01b0\u1eddng ho\u00e0n h\u1ea3o \u0111\u1ec3 ph\u1ea3n \u00e1nh t\u00ecnh tr\u1ea1ng b\u00e9o ph\u00ec, tuy nhi\u00ean BMI \u2265 30 c\u00f3 li\u00ean quan \u0111\u1ebfn g\u00e1nh n\u1eb7ng b\u1ec7nh t\u1eadt v\u00e0 t\u1ef7 l\u1ec7 t\u1eed vong t\u0103ng.<\/p>\n","protected":false},"author":123,"featured_media":35528,"comment_status":"closed","ping_status":"closed","template":"","meta":{"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"articles_categories":[1370],"articles_tags":[],"articles_topics":[1437],"articles_languages":[1375],"articles_filters":[],"class_list":["post-35499","articles","type-articles","status-publish","has-post-thumbnail","hentry","articles_categories-medical-content-vi","articles_languages-vietnamese-vi"],"_links":{"self":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/35499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles"}],"about":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/types\/articles"}],"author":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/comments?post=35499"}],"version-history":[{"count":0,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/35499\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media\/35528"}],"wp:attachment":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media?parent=35499"}],"wp:term":[{"taxonomy":"articles_categories","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_categories?post=35499"},{"taxonomy":"articles_tags","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_tags?post=35499"},{"taxonomy":"articles_topics","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_topics?post=35499"},{"taxonomy":"articles_languages","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_languages?post=35499"},{"taxonomy":"articles_filters","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_filters?post=35499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}