{"id":34654,"date":"2024-05-02T18:05:00","date_gmt":"2024-05-02T10:05:00","guid":{"rendered":"https:\/\/docquity.com\/?post_type=articles&p=34654"},"modified":"2025-02-11T13:40:09","modified_gmt":"2025-02-11T05:40:09","slug":"diem-tin-hoi-nghi-acc-2024-liberatehr-chat-uc-che-pcsk9-moi-lam-giam-hieu-qua-ldl-c","status":"publish","type":"articles","link":"https:\/\/docquity.com\/vi\/articles\/diem-tin-hoi-nghi-acc-2024-liberatehr-chat-uc-che-pcsk9-moi-lam-giam-hieu-qua-ldl-c\/","title":{"rendered":"\u0110i\u1ec3m tin H\u1ed9i ngh\u1ecb ACC 2024: LIBerateHR \u2013 Ch\u1ea5t \u1ee9c ch\u1ebf PCSK9 m\u1edbi l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 LDL-C"},"content":{"rendered":"\n

Th\u1eed nghi\u1ec7m LIBerate-HR \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o t\u1ea1i H\u1ed9i ngh\u1ecb Th\u01b0\u1eddng ni\u00ean c\u1ee7a Vi\u1ec7n Tim m\u1ea1ch Hoa K\u1ef3 (ACC) n\u0103m 2024. Th\u1eed nghi\u1ec7m LIBerate-HR \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 l\u00e0m r\u00f5 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a lerodalcibep, m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 proprotein convertase subtilisin\/kexin type 9 (PCSK9) m\u1edbi.<\/p>\n\n\n\n

Ch\u1ea5t \u1ee9c ch\u1ebf PCSK9 ch\u1eb9n protein PCSK9, gi\u00fap gan \u0111\u00e0o th\u1ea3i nhi\u1ec1u LDL-C h\u01a1n, t\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 LDL-C trong c\u01a1 th\u1ec3. Lerodalcibep \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi li\u1ec1u th\u1ea5p, kho\u1ea3ng 300 mg, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi 1.2 ml\/th\u00e1ng. Kh\u00e1c v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf PCSK9 kh\u00e1c trong nh\u00f3m, lerodalcibep kh\u00f4ng c\u1ea7n \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n trong t\u1ee7 l\u1ea1nh, ch\u1ec9 c\u1ea7n d\u00f9ng v\u1edbi li\u1ec1u th\u1ea5p v\u00e0 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 t\u1ef1 ti\u00eam t\u1ea1i nh\u00e0. C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e3 cho th\u1ea5y lerodalcibep c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 LDL-C c\u00f3 \u00fd ngh\u0129a trong 24 tu\u1ea7n theo d\u00f5i m\u00e0 kh\u00f4ng g\u00e2y t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng. Th\u1eed nghi\u1ec7m LIBerate-HR \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 theo d\u00f5i hi\u1ec7u l\u1ef1c v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a lerodalcibep trong th\u1eddi h\u1ea1n d\u00e0i h\u01a1n. B\u00e0i vi\u1ebft nh\u1eb1m t\u00f3m t\u1eaft nghi\u00ean c\u1ee9u LIBerate-HR.<\/p>\n\n\n\n


H\u00ecnh 1.<\/strong> T\u00f3m t\u1eaft th\u1eed nghi\u1ec7m LIBerate-HR<\/p>\n\n\n\n

T\u00f3m t\u1eaft nghi\u00ean c\u1ee9u LIBerate-HR<\/strong><\/h2>\n\n\n\n

LIBrate-HR l\u00e0 th\u1eedu nghi\u1ec7m ng\u1eabu nhi\u00ean, song song, m\u00f9 ba v\u00e0 c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c. Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh t\u1ea1i 11 qu\u1ed1c gia (Hoa K\u1ef3 v\u00e0 Ch\u00e2u \u00c2u). Nghi\u00ean c\u1ee9u ch\u1ec9 bao g\u1ed3m b\u1ec7nh nh\u00e2n \u2265 18 tu\u1ed5i \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc b\u1ec7nh tim m\u1ea1ch ho\u1eb7c c\u00f3 nguy c\u01a1 tim m\u1ea1ch cao v\u00e0 \u0111ang \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u1ed5n \u0111\u1ecbnh v\u1edbi statin.<\/p>\n\n\n\n

C\u00f3 t\u1ed5ng c\u1ed9ng 922 b\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u v\u1edbi tu\u1ed5i trung b\u00ecnh 64.5. Trong \u0111\u00f3 c\u00f3 45% b\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u l\u00e0 n\u1eef gi\u1edbi, 52% b\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u ch\u01b0a c\u00f3 ti\u1ec1n s\u1eed nh\u1ed3i m\u00e1u c\u01a1 tim hay \u0111\u1ed9t qu\u1ef5 nh\u01b0ng l\u1ea1i c\u00f3 nguy c\u01a1 cao v\u00e0 r\u1ea5t cao. N\u1ed3ng \u0111\u1ed9 LDL-C trung b\u00ecnh c\u1ee7a b\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u t\u1ea1i th\u1eddi \u0111i\u1ec3m b\u1eaft \u0111\u1ea7u nghi\u00ean c\u1ee9u l\u00e0 116 mg\/dl. C\u00f3 84% b\u1ec7nh nh\u00e2n \u0111ang \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t v\u1edbi statin, 17% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t lipid m\u00e1u v\u1edbi statin ph\u1ed1i h\u1ee3p v\u1edbi ezetimibe. C\u00f3 kho\u1ea3ng 25% b\u1ec7nh nh\u00e2n m\u1eafc k\u00e8m \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u00e0 10% b\u1ec7nh nh\u00e2n b\u1ecb t\u0103ng cholesterol m\u00e1u c\u00f3 t\u00ednh ch\u1ea5t gia \u0111\u00ecnh.<\/p>\n\n\n\n

B\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean th\u00e0nh 2 nh\u00f3m (t\u1ef7 l\u1ec7 2:1): (i) \u0111i\u1ec1u tr\u1ecb v\u1edbi 300 mg lerodalcibep (t\u01b0\u01a1ng \u1ee9ng 1.2 ml) x 1 l\u1ea7n\/th\u00e1ng v\u00e0 (ii) gi\u1ea3 d\u01b0\u1ee3c. B\u1ec7nh nh\u00e2n \u1edf c\u1ea3 2 nh\u00f3m \u0111\u1ec1u ti\u1ebfp t\u1ee5c ch\u1ebf \u0111\u1ed9 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft nh\u01b0 tr\u01b0\u1edbc \u0111\u00e2y v\u1edbi \u0111i\u1ec1u ch\u1ec9nh l\u1ed1i s\u1ed1ng v\u00e0 thu\u1ed1c h\u1ea1 lipid m\u00e1u.<\/p>\n\n\n\n

Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ch\u00ednh c\u1ee7a nghi\u00ean c\u1ee9u l\u00e0 t\u1ef7 l\u1ec7 thay \u0111\u1ed5i LDL-C c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi lerodalcibep so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c sau 50 \u2013 52 tu\u1ea7n theo d\u00f5i so v\u1edbi \u0111\u01b0\u1eddng n\u1ec1n. Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ph\u1ee5 bao g\u1ed3m t\u00ednh an to\u00e0n, thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 c\u1ee7a c\u00e1c lipdi kh\u00e1c c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nguy c\u01a1 tim m\u1ea1ch v\u00e0 t\u1ef7 l\u1ec7 b\u1ec7nh nh\u00e2n \u0111\u1ea1t LDL-C m\u1ee5c ti\u00eau theo khuy\u1ebfn c\u00e1o c\u1ee7a ACC\/AHA.<\/p>\n\n\n\n

K\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m LIBerate-HR<\/em><\/strong><\/h2>\n\n\n\n

Sau 1 n\u0103m theo d\u00f5i, 89% b\u1ec7nh nh\u00e2n ho\u00e0n th\u00e0nh nghi\u00ean c\u1ee9u, t\u1ef7 l\u1ec7 b\u1ec7nh nh\u00e2n r\u00fat kh\u1ecfi nghi\u00ean c\u1ee9u l\u00e0 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng gi\u1eefa nh\u00f3m \u0111i\u1ec1u tr\u1ecb v\u1edbi lerodalcibep v\u00e0 gi\u1ea3 \u0111\u01b0\u1ee3c. \u0110\u1ed1i v\u1edbi ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ch\u00ednh, lerodalcibep l\u00e0m gi\u1ea3m c\u00f3 \u00fd ngh\u0129a n\u1ed3ng \u0111\u1ed9 LDL-C so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, c\u1ee5 th\u1ec3 sau 52 tu\u1ea7n theo d\u00f5i, n\u1ed3ng \u0111\u1ed9 LDL-C gi\u1ea3m trung b\u00ecnh 56.3% \u1edf nh\u00f3m lerodalcibep, trong khi b\u1ec7nh nh\u00e2n nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c ch\u1ec9 gi\u1ea3m \u0111\u01b0\u1ee3c 0.14%.<\/p>\n\n\n\n

\u0110\u1ed1i v\u1edbi ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ph\u1ee5, c\u00f3 t\u1edbi h\u01a1n 90% b\u1ec7nh nh\u00e2n nh\u00f3m lerodalcibep gi\u1ea3m \u0111\u01b0\u1ee3c \u2265 50% n\u1ed3ng \u0111\u1ed9 LDL-C v\u00e0 \u0111\u1ea1t \u0111\u01b0\u1ee3c n\u1ed3ng \u0111\u1ed9 LDL-C m\u1ee5c ti\u00eau theo ph\u00e2n nh\u00f3m nguy c\u01a1 theo khy\u1ebfn c\u00e1o c\u1ee7a ACC\/AHA. \u1ede nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c, ch\u1ec9 c\u00f3 16% b\u1ec7nh nh\u00e2n gi\u1ea3m \u0111\u01b0\u1ee3c h\u01a1n \u2265 50% LDL-C v\u00e0 \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 LDL-C m\u1ee5c ti\u00eau theo khuy\u1ebfn c\u00e1o c\u1ee7a ACC\/AHA. N\u1ed3ng \u0111\u1ed9 apolipoprotein B c\u1ee7a b\u1ec7nh nh\u00e2n nh\u00f3m lerodalcibep gi\u1ea3m nhi\u1ec1u h\u01a1n 43% so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c sau 52 tu\u1ea7n theo d\u00f5i. N\u1ed3ng \u0111\u1ed9 lipoprotein (a) c\u1ee7a nh\u00f3m lerodalcibep gi\u1ea3m nhi\u1ec1u h\u01a1n 33% so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c sau 52 tu\u1ea7n theo d\u00f5i. \u0110\u1ed1i v\u1edbi ti\u00eau ch\u00ed an to\u00e0n, c\u00f3 4.2% b\u1ec7nh nh\u00e2n nh\u00f3m lerodalcibep ph\u1ea3i ng\u01b0ng thu\u1ed1c do t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c, t\u1ef7 l\u1ec7 n\u00e0y \u1edf nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c l\u00e0 4.6%. C\u00e1c t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i th\u01b0\u1eddng g\u1eb7p nh\u1ea5t bao g\u1ed3m \u0111\u1ecf, ng\u1ee9a ho\u1eb7c b\u1ea7m t\u1ea1i v\u1ecb tr\u00ed ti\u00eam (6.9% so v\u1edbi 0.3% \u1edf nh\u00f3m lerodalcibep so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c).<\/p>\n\n\n\n

K\u1ec3 t\u1eeb n\u0103m 2022, ACC v\u00e0 Hi\u1ec7p h\u1ed9i Tim m\u1ea1ch Ch\u00e2u \u00c2u (ESC) \u0111\u1ec1u khuy\u1ebfn c\u00e1o n\u1ed3ng \u0111\u1ed9 LDL-C m\u1ee5c ti\u00eau kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 55 mg\/dl \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh tim m\u1ea1ch c\u00f3 nguy c\u01a1 r\u1ea5t cao b\u1ecb nh\u1ed3i \u00e1u c\u01a1 tim ho\u1eb7c \u0111\u1ed9t qu\u1ef5 v\u00e0 kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 70 mg\/dl \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao. C\u1ea3 ACC v\u00e0 ESC \u0111\u1ec1u khuy\u1ebfn c\u00e1o b\u1ed5 sung th\u00eam thu\u1ed1c ki\u1ec3m so\u00e1t lipid m\u00e1u n\u1ebfu nh\u01b0 statin \u0111\u01a1n tr\u1ecb kh\u00f4ng th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n

K\u1ebft lu\u1eadn<\/strong><\/h2>\n\n\n\n

Th\u1eed nghi\u1ec7m LIBerate-HR cho th\u1ea5y \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh tim m\u1ea1ch ho\u1eb7c b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 cao \u0111ang \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u1ed5n \u0111\u1ecbnh v\u1edbi statin, lerodalcibep h\u1ed7 tr\u1ee3 c\u1ea3i thi\u1ec7n ki\u1ec3m so\u00e1t lipid m\u00e1u. Lerodalcibep gi\u1ea3m \u0111\u01b0\u1ee3c h\u01a1n 50% LDL-C so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c. Lerodalcibep c\u0169ng \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t v\u00e0 kh\u00f4ng g\u00e2y ra t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng.<\/p>\n\n\n\n

\n\n\n\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/h3>\n\n\n\n
    \n
  1. Aemerican College of Cardiology. Efficacy and Safety of Lerodalcibep in Patients at Very High and High Risk for Cardiovascular Disease – LIBerate-HR. Updated 07 Apr. Accessed date 22 Apr 2024. URL: https:\/\/www.acc.org\/latest-in-cardiology\/clinical-trials\/2024\/04\/05\/04\/34\/liberate-hr<\/li>\n\n\n\n
  2. Aemerican College of Cardiology. Novel PCSK9 Inhibitor Cut LDL Cholesterol Levels by More Than Half. Updated 07 Apr. Accessed date 22 Apr 2024. URL: https:\/\/www.acc.org\/About-ACC\/Press-Releases\/2024\/04\/07\/11\/25\/novel-pcsk9-inhibitor-cut-ldl-cholesterol-levels-by-more-than-half<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Th\u1eed nghi\u1ec7m LIBerate-HR \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o t\u1ea1i H\u1ed9i ngh\u1ecb Th\u01b0\u1eddng ni\u00ean c\u1ee7a Vi\u1ec7n Tim m\u1ea1ch Hoa K\u1ef3 (ACC) n\u0103m 2024.<\/p>\n","protected":false},"author":123,"featured_media":34732,"comment_status":"closed","ping_status":"closed","template":"","meta":{"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"articles_categories":[1370],"articles_tags":[],"articles_topics":[1436],"articles_languages":[1375],"articles_filters":[],"class_list":["post-34654","articles","type-articles","status-publish","has-post-thumbnail","hentry","articles_categories-medical-content-vi","articles_languages-vietnamese-vi"],"_links":{"self":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/34654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles"}],"about":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/types\/articles"}],"author":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/comments?post=34654"}],"version-history":[{"count":0,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/34654\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media\/34732"}],"wp:attachment":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media?parent=34654"}],"wp:term":[{"taxonomy":"articles_categories","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_categories?post=34654"},{"taxonomy":"articles_tags","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_tags?post=34654"},{"taxonomy":"articles_topics","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_topics?post=34654"},{"taxonomy":"articles_languages","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_languages?post=34654"},{"taxonomy":"articles_filters","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_filters?post=34654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}