{"id":13146,"date":"2023-12-22T15:11:15","date_gmt":"2023-12-22T07:11:15","guid":{"rendered":"https:\/\/docquity.com\/?post_type=articles&#038;p=13146"},"modified":"2025-02-11T13:38:40","modified_gmt":"2025-02-11T05:38:40","slug":"diem-tin-hoi-nghi-aha-2023-thuoc-ha-ap-moi-co-hieu-qua-keo-dai-trong-vong-sau-thang-chi-voi-mot-lieu-duy-nhat","status":"publish","type":"articles","link":"https:\/\/docquity.com\/vi\/articles\/diem-tin-hoi-nghi-aha-2023-thuoc-ha-ap-moi-co-hieu-qua-keo-dai-trong-vong-sau-thang-chi-voi-mot-lieu-duy-nhat\/","title":{"rendered":"\u0110i\u1ec3m tin H\u1ed9i ngh\u1ecb AHA 2023: Thu\u1ed1c h\u1ea1 \u00e1p m\u1edbi c\u00f3 hi\u1ec7u qu\u1ea3 k\u00e9o d\u00e0i trong v\u00f2ng s\u00e1u th\u00e1ng ch\u1ec9 v\u1edbi m\u1ed9t li\u1ec1u duy nh\u1ea5t"},"content":{"rendered":"\n<p>V\u00e0o ng\u00e0y 11 \u2013 13 th\u00e1ng 11 v\u1eeba qua, H\u1ed9i ngh\u1ecb Th\u01b0\u1eddng ni\u00ean c\u1ee7a Hi\u1ec7p h\u1ed9i Tim m\u1ea1ch Hoa K\u1ef3 (AHA) n\u0103m 2023 \u0111\u00e3 di\u1ec5n ra t\u1ea1i Philadelphia. H\u1ed9i ngh\u1ecb \u0111\u00e3 mang \u0111\u1ebfn nhi\u1ec1u k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u c\u00f3 t\u1ea7m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn th\u1ef1c h\u00e0nh. Nh\u1eb1m gi\u00fap qu\u00fd v\u1ecb \u0111\u1ed3ng nghi\u1ec7p n\u1eafm b\u1eaft nh\u1eefng tin t\u1ee9c t\u1ed1i quan tr\u1ecdng, ch\u00fang t\u00f4i xin t\u00f3m t\u1eaft b\u00e0i tr\u00ecnh b\u00e0y v\u1ec1 k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u KARDIA \u2013 1, li\u00ean quan \u0111\u1ebfn hi\u1ec7u l\u1ef1c v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a zilebesiran trong \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p [1].<\/p>\n\n\n\n<p><strong>\u0110i\u1ec3m ch\u00ednh<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng pha 2 \u0111\u00e3 cho th\u1ea5y zilebesiran li\u1ec1u \u0111\u01a1n an to\u00e0n v\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 h\u1ea1 \u00e1p k\u00e9o d\u00e0i t\u1edbi 6 th\u00e1ng \u1edf b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p m\u1ee9c \u0111\u1ed9 nh\u1eb9 &#8211; trung b\u00ecnh.<\/li>\n\n\n\n<li>D\u1ef1a tr\u00ean nh\u1eefng d\u1eef li\u1ec7u hi\u1ec7n c\u00f3, zilebesiran l\u00e0 l\u1ef1a ch\u1ecdn h\u1ea1 \u00e1p c\u00f3 ti\u1ec1m n\u0103ng, h\u1ed7 tr\u1ee3 b\u1ec7nh nh\u00e2n c\u1ea3i thi\u1ec7n tu\u00e2n th\u1ee7 \u0111i\u1ec1u tr\u1ecb, t\u1eeb \u0111\u00f3 t\u0103ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb v\u00e0 gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p.<\/li>\n<\/ul>\n\n\n\n<p><strong>Zilebesiran<\/strong><\/p>\n\n\n\n<p>Zilebesiran l\u00e0 m\u1ed9t t\u00e1c nh\u00e2n RNA interference \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n. Zilebesiran c\u00f3 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng nh\u1eafm \u0111\u00edch v\u00e0o angiotensinogen (AGT). Angiotensinogen \u0111\u01b0\u1ee3c s\u1ea3n sinh ch\u1ee7 y\u1ebfu \u1edf gan v\u00e0 chi ph\u1ed1i v\u00e0o qu\u00e1 tr\u00ecnh \u0111i\u1ec1u h\u00f2a huy\u1ebft \u00e1p. Trong nghi\u00ean c\u1ee9u KARDIA \u2013 1, zilebesiran \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi \u0111\u01b0\u1eddng ti\u00eam d\u01b0\u1edbi da [1, 2].<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/dxecch.stripocdn.email\/content\/guids\/CABINET_c070182a7e87148b564a2791b066900c51867a58d20410cc9277921c8ac66c6d\/images\/kardia1.png\" alt=\"\" \/><\/figure>\n\n\n\n<p><strong>H\u00ecnh 1.<\/strong>&nbsp;T\u00f3m t\u1eaft th\u1eed nghi\u1ec7m KARDIA \u2013 1<\/p>\n\n\n\n<p><strong>T\u00f3m t\u1eaft nghi\u00ean c\u1ee9u<\/strong><\/p>\n\n\n\n<p>Th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean, c\u00f3 \u0111\u1ed1i ch\u1ee9ng, m\u00f9 \u0111\u00f4i \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 l\u00e0m r\u00f5 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u l\u1ef1c c\u1ee7a zilebesiran \u1edf b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p m\u1ee9c \u0111\u1ed9 nh\u1eb9 &#8211; trung b\u00ecnh (huy\u1ebft \u00e1p t\u00e2m thu trong kho\u1ea3ng 135 \u2013 160 mmHg) ch\u01b0a \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb ho\u1eb7c \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u1ed5n \u0111\u1ecbnh v\u1edbi 2 thu\u1ed1c h\u1ea1 \u00e1p. Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean 394 b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p. M\u1ee9c huy\u1ebft \u00e1p t\u00e2m thu trung b\u00ecnh c\u1ee7a nh\u1eefng b\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u ghi nh\u1eadn l\u00e0 142 mmHg. B\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean th\u00e0nh 5 nh\u00f3m: (i) \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran li\u1ec1u 150 mg\/6 th\u00e1ng; (ii) \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran li\u1ec1u 300 mg\/6 th\u00e1ng; (iii) \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran li\u1ec1u 600 mg\/6 th\u00e1ng; (iv) \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran li\u1ec1u 300 mg\/3 th\u00e1ng; (v) gi\u1ea3 d\u01b0\u1ee3c [1, 2].<\/p>\n\n\n\n<p>K\u1ebft qu\u1ea3 ph\u00e2n t\u00edch cho th\u1ea5y nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran \u0111\u01b0\u1eddng ti\u00eam d\u01b0\u1edbi da (v\u1edbi m\u1ecdi li\u1ec1u) gi\u1ea3m \u0111\u01b0\u1ee3c trung b\u00ecnh nhi\u1ec1u h\u01a1n 10 mmHg huy\u1ebft \u00e1p t\u00e2m thu 24 gi\u1edd v\u00e0 c\u00f3 n\u1ed3ng \u0111\u1ed9 AGT gi\u1ea3m nhi\u1ec1u h\u01a1n 90% so v\u1edbi nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi gi\u1ea3 d\u01b0\u1ee3c [1, 2].<\/p>\n\n\n\n<p>T\u1ea1i th\u1eddi \u0111i\u1ec3m 3 th\u00e1ng theo d\u00f5i, nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran li\u1ec1u 300 mg v\u00e0 600 mg c\u00f3 huy\u1ebft \u00e1p t\u00e2m thu 24 gi\u1edd gi\u1ea3m trung b\u00ecnh \u2265 15 mmHg. T\u1ea1i th\u1eddi \u0111i\u1ec3m 6 th\u00e1ng theo d\u00f5i, nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran gi\u1ea3m \u0111\u01b0\u1ee3c trung b\u00ecnh \u2265 20 mmHg huy\u1ebft \u00e1p t\u00e2m thu 24 gi\u1edd m\u00e0 kh\u00f4ng c\u1ea7n b\u1ed5 sung thu\u1ed1c h\u1ea1 \u00e1p kh\u00e1c. B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran c\u0169ng c\u00f3 xu h\u01b0\u1edbng \u0111\u1ea1t m\u1ee9c huy\u1ebft \u00e1p t\u00e2m thu 24 gi\u1edd \u2264 130 mmHg nhi\u1ec1u h\u01a1n so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c [1, 2].<\/p>\n\n\n\n<p>Kh\u00f4ng nh\u1eefng v\u1eady, b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi zilebesiran (v\u1edbi m\u1ecdi li\u1ec1u) gi\u1ea3m \u0111\u01b0\u1ee3c huy\u1ebft \u00e1p t\u00e2m thu c\u00f3 \u00fd ngh\u0129a m\u1ed9t c\u00e1ch \u1ed5n \u0111\u1ecbnh \u1edf c\u1ea3 ban ng\u00e0y v\u00e0 ban \u0111\u00eam. T\u1ef7 l\u1ec7 th\u1ea5p c\u00e1c bi\u1ebfn c\u1ed1 c\u00f3 h\u1ea1i li\u00ean quan \u0111\u1ebfn zilebesiran \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. Bi\u1ebfn c\u1ed1 c\u00f3 h\u1ea1i th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 ph\u1ea3n \u1ee9ng nh\u1eb9 t\u1ea1i ch\u1ed7 ti\u00eam. Kh\u00f4ng c\u00f3 s\u1ef1 thay \u0111\u1ed5i v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng tr\u00ean gan hay th\u1eadn \u0111\u01b0\u1ee3c quan s\u00e1t [1, 2].<\/p>\n\n\n\n<p><strong>K\u1ebft lu\u1eadn<\/strong><\/p>\n\n\n\n<p>Nh\u01b0 v\u1eady, nghi\u00ean c\u1ee9u KARDIA \u2013 1 cho th\u1ea5y zilebesiran li\u1ec1u h\u00e0ng qu\u00fd hay m\u1ed7i 6 th\u00e1ng \u0111\u1ec1u hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n \u0111\u1ec3 h\u1ea1 huy\u1ebft \u00e1p \u1edf b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p ch\u01b0a \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t. C\u1ea7n l\u01b0u \u00fd r\u1eb1ng gi\u1ea3m \u0111\u01b0\u1ee3c huy\u1ebft \u00e1p t\u00e2m thu \u2265 5 mg c\u00f3 li\u00ean quan \u0111\u1ebfn gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch [1, 2].<\/p>\n\n\n\n<p><strong>B\u00e0n lu\u1eadn<\/strong><\/p>\n\n\n\n<p>T\u0103ng huy\u1ebft \u00e1p kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t l\u00e0 nguy\u00ean nh\u00e2n c\u1ee7a nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p t\u1eed vong v\u00e0 bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng c\u1ee7a b\u1ec7nh t\u1eadt, do v\u1eady, nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p l\u00e2u d\u00e0i l\u00e0 m\u1ed9t nhu c\u1ea7u c\u1ea7n thi\u1ebft. Nghi\u00ean c\u1ee9u KARDIA \u2013 1 \u0111\u00e3 cho th\u1ea5y tri\u1ec3n v\u1ecdng c\u1ee7a zilebesiran trong ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p.<\/p>\n\n\n\n<p>KARDIA \u2013 1 ch\u1ec9 bao g\u1ed3m c\u00e1c b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p m\u1ee9c \u0111\u1ed9 nh\u1eb9 &#8211; trung b\u00ecnh. H\u01a1n n\u1eefa, th\u1eddi gian theo d\u00f5i ch\u1ec9 h\u1ea1n ch\u1ebf \u1edf m\u1ee9c 6 th\u00e1ng. Trong t\u01b0\u01a1ng lai c\u1ea7n c\u00f3 c\u00e1c nghi\u00ean c\u1ee9u theo d\u00f5i t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 h\u1ea1 \u00e1p trong th\u1eddi gian d\u00e0i h\u01a1n, \u0111\u1ed3ng th\u1eddi c\u0169ng c\u1ea7n c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e1nh gi\u00e1 k\u1ebft c\u1ee5c tim m\u1ea1ch c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng zilebesiran.<\/p>\n\n\n\n<p><strong>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>American Heart Association Scientific Sessions 2023, Late-Breaking Science Abstract in LBS.04. Single dose of zilebesiran safely and effectively lowered blood pressure for six months. URL:&nbsp;<a href=\"https:\/\/newsroom.heart.org\/news\/single-dose-of-zilebesiran-safely-and-effectively-lowered-blood-pressure-for-six-months\">https:\/\/newsroom.heart.org\/news\/single-dose-of-zilebesiran-safely-and-effectively-lowered-blood-pressure-for-six-months<\/a><\/li>\n\n\n\n<li>Desai AS, Webb DJ, Taubel J, Casey S, Cheng Y, Robbie GJ, Foster D, Huang SA, Rhyee S, Sweetser MT, Bakris GL. Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023 Jul 20;389(3):228-238. doi: 10.1056\/NEJMoa2208391.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>V\u00e0o ng\u00e0y 11 \u2013 13 th\u00e1ng 11 v\u1eeba qua, H\u1ed9i ngh\u1ecb Th\u01b0\u1eddng ni\u00ean c\u1ee7a Hi\u1ec7p h\u1ed9i Tim m\u1ea1ch Hoa K\u1ef3 (AHA) n\u0103m 2023 \u0111\u00e3 di\u1ec5n ra t\u1ea1i Philadelphia. H\u1ed9i ngh\u1ecb \u0111\u00e3 mang \u0111\u1ebfn nhi\u1ec1u k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u c\u00f3 t\u1ea7m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn th\u1ef1c h\u00e0nh. Nh\u1eb1m gi\u00fap qu\u00fd v\u1ecb \u0111\u1ed3ng nghi\u1ec7p n\u1eafm b\u1eaft nh\u1eefng tin &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/docquity.com\/vi\/articles\/diem-tin-hoi-nghi-aha-2023-thuoc-ha-ap-moi-co-hieu-qua-keo-dai-trong-vong-sau-thang-chi-voi-mot-lieu-duy-nhat\/\"> <span class=\"screen-reader-text\">\u0110i\u1ec3m tin H\u1ed9i ngh\u1ecb AHA 2023: Thu\u1ed1c h\u1ea1 \u00e1p m\u1edbi c\u00f3 hi\u1ec7u qu\u1ea3 k\u00e9o d\u00e0i trong v\u00f2ng s\u00e1u th\u00e1ng ch\u1ec9 v\u1edbi m\u1ed9t li\u1ec1u duy nh\u1ea5t<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":123,"featured_media":13151,"comment_status":"closed","ping_status":"closed","template":"","meta":{"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"articles_categories":[1370],"articles_tags":[],"articles_topics":[1436],"articles_languages":[1375],"articles_filters":[],"class_list":["post-13146","articles","type-articles","status-publish","has-post-thumbnail","hentry","articles_categories-medical-content-vi","articles_languages-vietnamese-vi"],"_links":{"self":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/13146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles"}],"about":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/types\/articles"}],"author":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/comments?post=13146"}],"version-history":[{"count":0,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/13146\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media\/13151"}],"wp:attachment":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media?parent=13146"}],"wp:term":[{"taxonomy":"articles_categories","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_categories?post=13146"},{"taxonomy":"articles_tags","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_tags?post=13146"},{"taxonomy":"articles_topics","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_topics?post=13146"},{"taxonomy":"articles_languages","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_languages?post=13146"},{"taxonomy":"articles_filters","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_filters?post=13146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}