{"id":12372,"date":"2023-11-08T19:01:19","date_gmt":"2023-11-08T11:01:19","guid":{"rendered":"https:\/\/docquity.com\/?post_type=articles&p=12372"},"modified":"2025-02-11T13:37:44","modified_gmt":"2025-02-11T05:37:44","slug":"chat-chu-van-thu-the-glp-1-lam-tang-nguy-co-mac-bien-chung-nghiem-trong-tren-duong-tieu-hoa","status":"publish","type":"articles","link":"https:\/\/docquity.com\/vi\/articles\/chat-chu-van-thu-the-glp-1-lam-tang-nguy-co-mac-bien-chung-nghiem-trong-tren-duong-tieu-hoa\/","title":{"rendered":"Ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 l\u00e0m t\u0103ng nguy c\u01a1 m\u1eafc bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a"},"content":{"rendered":"\n

Semaglutide v\u00e0 liraglutide l\u00e0 nh\u1eefng ho\u1ea1t ch\u1ea5t thu\u1ed9c nh\u00f3m thu\u1ed1c ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 glucagon-like peptide-1 (GLP-1), ngo\u00e0i ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft, nh\u1eefng ho\u1ea1t ch\u1ea5t n\u00e0y hi\u1ec7n nay c\u00f2n \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi vai tr\u00f2 m\u1edbi l\u00e0 ki\u1ec3m so\u00e1t c\u00e2n n\u1eb7ng v\u00e0 gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch. L\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb c\u1ee7a nh\u00f3m thu\u1ed1c ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 l\u00e0 kh\u00f4ng th\u1ec3 b\u00e0n c\u00e3i, tuy nhi\u00ean, m\u1ed9t v\u00e0i b\u1eb1ng ch\u1ee9ng \u0111\u00e3 cho th\u1ea5y nh\u00f3m ho\u1ea1t ch\u1ea5t n\u00e0y l\u00e0m t\u0103ng nguy c\u01a1 m\u1eafc c\u00e1c bi\u1ebfn ch\u1ee9ng hi\u1ebfm g\u1eb7p nh\u01b0ng nghi\u00eam tr\u1ecdng tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Journal of the American Medical Association<\/em>1, 2.<\/em><\/p>\n\n\n\n

K\u1ebft qu\u1ea3 ch\u00ednh c\u1ee7a nghi\u00ean c\u1ee9u<\/h2>\n\n\n\n

Nghi\u00ean c\u1ee9u bao g\u1ed3m 4144 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng liraglutide, 613 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng semaglutide, 654 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng naltrexone\/burpropion trong giai \u0111o\u1ea1n 2006 \u2013 20202. Ti\u00eau ch\u00ed ch\u1ecdn c\u1ee7a nghi\u00ean c\u1ee9u bao g\u1ed3m b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed b\u00e9o ph\u00ec v\u00e0 ti\u00eau ch\u00ed lo\u1ea1i tr\u1eeb bao g\u1ed3m b\u1ec7nh nh\u00e2n m\u1eafc \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ho\u1eb7c \u0111ang \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n nh\u00f3m thu\u1ed1c kh\u00e1c \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft2. K\u1ebft qu\u1ea3 cho th\u1ea5y nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 c\u00f3 nguy c\u01a1 b\u1ecb vi\u00eam t\u1ee5y c\u1ea5p cao h\u01a1n g\u1ea5p 9 l\u1ea7n so v\u1edbi nh\u00f3m b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng naltrexone\/burpropion2. T\u01b0\u01a1ng t\u1ef1, ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 c\u0169ng l\u00e0m t\u0103ng c\u00f3 \u00fd ngh\u0129a nguy c\u01a1 t\u1eafc ru\u1ed9t v\u00e0 li\u1ec7t d\u1ea1 d\u00e0y so v\u1edbi naltrexone\/burpropion. C\u1ee5 th\u1ec3, ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 l\u00e0m t\u0103ng 4 l\u1ea7n nguy c\u01a1 t\u1eafc ru\u1ed9t v\u00e0 h\u01a1n 3.5 l\u1ea7n nguy c\u01a1 li\u1ec7t d\u1ea1 d\u00e0y2. Ngo\u00e0i ra, t\u1ef7 l\u1ec7 b\u1ec7nh nh\u00e2n m\u1eafc c\u00e1c b\u1ec7nh l\u00fd \u0111\u01b0\u1eddng m\u1eadt c\u0169ng \u0111\u01b0\u1ee3c ghi nh\u1eadn cao h\u01a1n \u1edf nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1, tuy nhi\u00ean s\u1ef1 kh\u00e1c bi\u1ec7t n\u00e0y kh\u00f4ng c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea (11.7 bi\u1ebfn c\u1ed1\/100 ng\u01b0\u1eddi \u2013 n\u0103m \u0111\u1ed1i v\u1edbi semaglutide, 18.6 \u0111\u1ed1i v\u1edbi liraglutide v\u00e0 12.6 \u0111\u1ed1i v\u1edbi naltrexone\/burpropion)2.<\/p>\n\n\n\n

Nh\u1eefng b\u00e1o c\u00e1o tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a kh\u00e1c<\/h2>\n\n\n\n

Nghi\u00ean c\u1ee9u n\u00e0y l\u00e0 m\u1ed9t b\u1eb1ng ch\u1ee9ng quan tr\u1ecdng, kh\u1eb3ng \u0111\u1ecbnh h\u1ed3 s\u01a1 an to\u00e0n c\u1ee7a ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1. Nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 c\u1ee1 m\u1eabu l\u1edbn nh\u1ea5t v\u1ec1 t\u00ednh an to\u00e0n c\u1ee7a semaglutide v\u00e0 liraglutide nh\u01b0ng kh\u00f4ng ph\u1ea3i l\u00e0 nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean cho th\u1ea5y nh\u1eefng nguy c\u01a1 tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u1ee7a nh\u00f3m thu\u1ed1c n\u00e0y. V\u00e0o ng\u00e0y 28\/09\/2023, C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea7m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 th\u00f4ng b\u00e1o y\u00eau c\u1ea7u nh\u00e0 s\u1ea3n xu\u1ea5t b\u1ed5 sung c\u1ea3nh b\u00e1o li\u00ean quan \u0111\u1ebfn \u0111\u01b0\u1eddng ti\u00eau h\u00f3a tr\u00ean nh\u00e3n thu\u1ed1c semaglutide1, 3.<\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u1ed3ng th\u1eddi c\u0169ng n\u00eau l\u00ean t\u1ea7m quan tr\u1ecdng c\u1ee7a nh\u00e2n vi\u00ean y t\u1ebf c\u00f3 chuy\u00ean m\u00f4n trong vi\u1ec7c k\u00ea \u0111\u01a1n thu\u1ed1c ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1, c\u00f9ng v\u1edbi s\u1ef1 theo d\u00f5i b\u1ec7nh nh\u00e2n s\u00e1t sao. V\u1edbi b\u1ed1i c\u1ea3nh t\u0103ng c\u01b0\u1eddng t\u1ef7 l\u1ec7 m\u1eafc b\u00e9o ph\u00ec hi\u1ec7n nay, c\u00f9ng v\u1edbi nh\u00f3m d\u00e2n s\u1ed1 \u0111\u00edch r\u1ed9ng c\u1ee7a c\u00e1c ho\u1ea1t ch\u1ea5t thu\u1ed9c nh\u00f3m ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1, th\u00ec vi\u1ec7c ki\u1ec3m so\u00e1t k\u00ea \u0111\u01a1n, \u0111\u00e1nh gi\u00e1 l\u1ee3i \u00edch\/nguy c\u01a1 c\u00e0ng tr\u1edf n\u00ean quan tr\u1ecdng.<\/p>\n\n\n\n

B\u00e0n lu\u1eadn<\/h2>\n\n\n\n

Nh\u01b0 v\u1eady, b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 c\u00f3 nguy c\u01a1 b\u1ecb vi\u00eam t\u1ee5y cao g\u1ea5p 9 l\u1ea7n. Kh\u00f4ng nh\u1eefng v\u1eady, nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y c\u0169ng c\u00f3 nguy c\u01a1 b\u1ecb t\u1eafc ru\u1ed9t cao g\u1ea5p 4 l\u1ea7n v\u00e0 nguy c\u01a1 b\u1ecb li\u1ec7t d\u1ea1 d\u00e0y cao g\u1ea5p 3.5 l\u1ea7n2. V\u1edbi k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u n\u00e0y, \u0111\u1ed9i ng\u0169 nh\u00e2n vi\u00ean y t\u1ebf c\u1ea7n ph\u1ea3i t\u0103ng c\u01b0\u1eddng c\u1ea3nh gi\u00e1c v\u00e0 nh\u1eadn th\u1ee9c v\u1ec1 nh\u1eefng bi\u1ebfn c\u1ed1 c\u00f3 h\u1ea1i c\u1ee7a ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 \u0111\u1ec3 \u0111\u01b0a ra k\u1ebf ho\u1ea1ch \u0111i\u1ec1u tr\u1ecb, theo d\u00f5i v\u00e0 d\u1ef1 ph\u00f2ng ph\u00f9 h\u1ee3p cho b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n

\u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng l\u1ef1a ch\u1ecdn ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft nh\u1edd v\u00e0o nh\u1eefng l\u1ee3i \u00edch c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi nguy c\u01a1 tim m\u1ea1ch th\u01b0\u1eddng c\u00f3 l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i h\u01a1n nguy c\u01a1 khi \u0111i\u1ec1u tr\u1ecb. Tuy nhi\u00ean, \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh v\u00e0 ch\u1ec9 s\u1eed d\u1ee5ng ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 \u0111\u1ec3 ki\u1ebfm so\u00e1t c\u00e2n n\u1eb7ng th\u00ec c\u1ea7n ph\u1ea3i l\u01b0u \u00fd v\u00e0 \u0111\u00e1nh gi\u00e1 k\u1ef9 l\u01b0\u1ee1ng c\u00e1n c\u00e2n l\u1ee3i \u00edch \u2013 nguy c\u01a1.<\/p>\n\n\n\n

B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c bi\u00ean so\u1ea1n b\u1edfi \u0111\u1ed9i ng\u0169 Y khoa Docquity<\/em><\/p>\n\n\n\n

\n\n\n\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h3>\n\n\n\n
    \n
  1. Damian McNamara. GLP-1 Agonists Linked to Higher Risk for Rare but Serious GI Complications. Medscape. Updated 05 Oct 2023. Accessed date 11 Oct 2023. URL: https:\/\/www.medscape.com\/viewarticle\/997128<\/li>\n\n\n\n
  2. Sodhi M, Rezaeianzadeh R, Kezouh A, Etminan M. Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss. JAMA. Published online October 05, 2023. doi:10.1001\/jama.2023.19574<\/li>\n\n\n\n
  3. Ozempic Drug Safety-related Labeling Changes (SrLC). U.S. Food and Drug Administration. Accessed date 11 Oct 2023. URL: https:\/\/www.accessdata.fda.gov\/scripts\/cder\/safetylabelingchanges\/index.cfm?event=searchdetail.page&DrugNameID=2183<\/li>\n<\/ol>\n\n\n\n

    Th\u1ea3o lu\u1eadn c\u00f9ng c\u00e1c b\u00e1c s\u0129 gi\u1ecfi nh\u1ea5t trong khu v\u1ef1c. T\u00ecm hi\u1ec3u n\u1ed9i dung y khoa v\u00e0 tham d\u1ef1 c\u00e1c ch\u01b0\u01a1ng tr\u00ecnh \u0111\u00e0o t\u1ea1o \u0111\u01b0\u1ee3c c\u00e1c chuy\u00ean gia \u0111\u1ea7u ng\u00e0nh x\u00e2y d\u1ef1ng. Tham gia c\u00e1c bu\u1ed5i th\u1ea3o lu\u1eadn tr\u1ef1c tuy\u1ebfn c\u00f9ng c\u00e1c chuy\u00ean gia qu\u1ed1c t\u1ebf Docquity<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Semaglutide v\u00e0 liraglutide l\u00e0 nh\u1eefng ho\u1ea1t ch\u1ea5t thu\u1ed9c nh\u00f3m thu\u1ed1c ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 glucagon-like peptide-1 (GLP-1), ngo\u00e0i ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft, nh\u1eefng ho\u1ea1t ch\u1ea5t n\u00e0y hi\u1ec7n nay c\u00f2n \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi vai tr\u00f2 m\u1edbi l\u00e0 ki\u1ec3m so\u00e1t c\u00e2n n\u1eb7ng v\u00e0 gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch. L\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb c\u1ee7a nh\u00f3m thu\u1ed1c ch\u1ee7 …<\/p>\n

    Ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 l\u00e0m t\u0103ng nguy c\u01a1 m\u1eafc bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a<\/span> Read More »<\/a><\/p>\n","protected":false},"author":123,"featured_media":12513,"comment_status":"closed","ping_status":"closed","template":"","meta":{"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"articles_categories":[1370],"articles_tags":[],"articles_topics":[1437],"articles_languages":[1375],"articles_filters":[],"class_list":["post-12372","articles","type-articles","status-publish","has-post-thumbnail","hentry","articles_categories-medical-content-vi","articles_languages-vietnamese-vi"],"_links":{"self":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/12372","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles"}],"about":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/types\/articles"}],"author":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/comments?post=12372"}],"version-history":[{"count":0,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/12372\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media\/12513"}],"wp:attachment":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media?parent=12372"}],"wp:term":[{"taxonomy":"articles_categories","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_categories?post=12372"},{"taxonomy":"articles_tags","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_tags?post=12372"},{"taxonomy":"articles_topics","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_topics?post=12372"},{"taxonomy":"articles_languages","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_languages?post=12372"},{"taxonomy":"articles_filters","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_filters?post=12372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}