{"id":12367,"date":"2023-11-08T18:51:36","date_gmt":"2023-11-08T10:51:36","guid":{"rendered":"https:\/\/docquity.com\/?post_type=articles&p=12367"},"modified":"2025-02-11T13:37:44","modified_gmt":"2025-02-11T05:37:44","slug":"mot-vai-thong-tin-ve-thuoc-het-han","status":"publish","type":"articles","link":"https:\/\/docquity.com\/vi\/articles\/mot-vai-thong-tin-ve-thuoc-het-han\/","title":{"rendered":"M\u1ed9t v\u00e0i th\u00f4ng tin v\u1ec1 thu\u1ed1c h\u1ebft h\u1ea1n"},"content":{"rendered":"\n

T\u00ecnh hu\u1ed1ng<\/h2>\n\n\n\n

M\u1ed9t b\u1ec7nh nh\u00e2n h\u1ecfi b\u1ea1n li\u1ec7u r\u1eb1ng b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng b\u00fat ti\u00eam adrenaline \u0111\u00e3 h\u1ebft h\u1ea1n. B\u1ea1n s\u1ebd t\u01b0 v\u1ea5n th\u1ebf n\u00e0o?<\/p>\n\n\n\n

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  1. Adrenaline th\u01b0\u1eddng kh\u00f4ng c\u00f2n hi\u1ec7u qu\u1ea3 sau ng\u00e0y h\u1ebft h\u1ea1n<\/li>\n\n\n\n
  2. Adrenaline sau ng\u00e0y h\u1ebft h\u1ea1n c\u00f3 th\u1ec3 nguy hi\u1ec3m<\/li>\n\n\n\n
  3. B\u00fat ti\u00eam adrenaline v\u1eabn c\u00f2n c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho t\u1edbi 2 n\u0103m sau ng\u00e0y h\u1ebft h\u1ea1n<\/li>\n<\/ol>\n\n\n\n

    L\u1ef1a ch\u1ecdn C \u0111\u01b0\u1ee3c xem nh\u01b0 l\u00e0 l\u1ef1a ch\u1ecdn ch\u00ednh x\u00e1c nh\u1ea5t. Ng\u00e0y h\u1ebft h\u1ea1n kh\u00f4ng ph\u1ea3i l\u00e0 ng\u00e0y ho\u1ea1t ch\u1ea5t trong thu\u1ed1c kh\u00f4ng c\u00f2n hi\u1ec7u qu\u1ea3 hay s\u1ebd tr\u1edf n\u00ean \u0111\u1ed9c h\u1ea1i. Th\u1ef1c t\u1ebf, ng\u00e0y h\u1ebft h\u1ea1n l\u00e0 th\u1eddi \u0111i\u1ec3m lu\u1eadt ph\u00e1p b\u1eaft bu\u1ed9c c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t thu\u1ed1c ph\u1ea3i \u0111\u01b0a ra, \u0111\u1ea3m b\u1ea3o r\u1eb1ng t\u1ea1i trong th\u1eddi h\u1ea1n s\u1eed d\u1ee5ng, thu\u1ed1c \u1ed5n \u0111\u1ecbnh, duy tr\u00ec \u0111\u01b0\u1ee3c hi\u1ec7u l\u1ef1c, ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 \u0111\u1ed9 tinh khi\u1ebft khi \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n d\u01b0\u1edbi \u0111i\u1ec1u ki\u1ec7n \u0111\u01b0\u1ee3c ghi tr\u00ean nh\u00e3n1, 2.<\/p>\n\n\n\n

    B\u1eb1ng ch\u1ee9ng v\u1ec1 thu\u1ed1c h\u1ebft h\u1ea1n<\/h2>\n\n\n\n

    M\u1ed9t nghi\u00ean c\u1ee9u c\u1ee7a Weir v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh, so s\u00e1nh hi\u1ec7u l\u1ef1c c\u1ee7a 3 b\u00fat ti\u00eam epinephrine 30 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y h\u1ebft h\u1ea1n s\u1eed d\u1ee5ng v\u00e0 b\u00fat ti\u00eam epinephrine \u0111ang trong th\u1eddi h\u1ea1n s\u1eed d\u1ee5ng. N\u1ed3ng \u0111\u1ed9 c\u1ee7a epinephrine trong 4 b\u00fat ti\u00eam \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh b\u1edfi s\u1eafc k\u00fd l\u1ecfng kh\u1ed1i ph\u1ed5 v\u00e0 c\u1ed9ng h\u01b0\u1edfng t\u1eeb h\u1ea1t nh\u00e2n. L\u01b0\u1ee3ng thu\u1ed1c trong 3 b\u00fat ti\u00eam h\u1ebft h\u1ea1n 30 th\u00e1ng c\u0169ng \u0111\u01b0\u1ee3c \u0111em \u0111i c\u1ea5y t\u00ecm vi khu\u1ea9n v\u00e0 n\u1ea5m. K\u1ebft qu\u1ea3 cho th\u1ea5y n\u1ed3ng \u0111\u1ed9 c\u1ee7a epinephrine trong c\u1ea3 4 b\u00fat ti\u00eam kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a. K\u1ebft qu\u1ea3 c\u1ea5y khu\u1ea9n v\u00e0 n\u1ea5m c\u0169ng \u00e2m t\u00ednh3. T\u01b0\u01a1ng t\u1ef1, m\u1ed9t nghi\u00ean c\u1ee9u c\u1ee7a Rachid v\u00e0 c\u1ed9ng s\u1ef1 c\u0169ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh v\u1ec1 b\u00fat ti\u00eam epinephrine h\u1ebft h\u1ea1n t\u1eeb 3 \u2013 36 th\u00e1ng4. K\u1ebft qu\u1ea3 cho th\u1ea5y n\u1ed3ng \u0111\u1ed9 c\u1ee7a epinephrine trong c\u00e1c m\u1eabu giao \u0111\u1ed9ng t\u1eeb 84 \u2013 101%. T\u1ea5t c\u1ea3 c\u00e1c b\u00fat ti\u00eam epinephrine \u0111\u00e3 h\u1ebft h\u1ea1n < 24 th\u00e1ng \u0111\u1ec1u c\u00f3 li\u1ec1u epinephrine > 90% li\u1ec1u epinephrine \u0111\u01b0\u1ee3c ghi tr\u00ean nh\u00e3n4. Cantrell v\u00e0 c\u1ed9ng s\u1ef1 c\u0169ng ti\u1ebfn h\u00e0nh nghi\u00ean c\u1ee9u v\u1edbi m\u1ee5c \u0111\u00edch t\u01b0\u01a1ng t\u1ef1, tr\u00ean t\u1ed5ng c\u1ed9ng 40 b\u00fat ti\u00eam epinephrine \u0111\u00e3 h\u1ebft h\u1ea1n trong kho\u1ea3ng 1 \u2013 50 th\u00e1ng [5]. \u0110a s\u1ed1 b\u00fat ti\u00eam s\u1eed d\u1ee5ng trong nghi\u00ean c\u1ee9u \u0111\u1ec1u kh\u00f4ng \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n trong \u0111i\u1ec1u ki\u1ec7n l\u00fd t\u01b0\u1edfng \u0111\u01b0\u1ee3c ghi ch\u00fa tr\u00ean nh\u00e3n5. K\u1ebft qu\u1ea3 c\u00f3 t\u1ed5ng c\u1ed9ng 56% b\u00fat ti\u00eam epinephrine \u0111\u1ea1t > 90% n\u1ed3ng \u0111\u1ed9 epinephrine \u0111\u01b0\u1ee3c ghi ch\u00fa tr\u00ean nh\u00e3n5.<\/p>\n\n\n\n

    Ch\u01b0\u01a1ng tr\u00ecnh nghi\u00ean c\u1ee9u Self Life Extension Program (SLEP) ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m tr\u00ean 122 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u1eeb h\u01a1n 3500 l\u00f4 s\u1ea3n xu\u1ea5t [6]. K\u1ebft qu\u1ea3 th\u00ed nghi\u1ec7m v\u00e0 \u0111\u00e1nh gi\u00e1 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh cho th\u1ea5y 88% l\u00f4 c\u00f3 h\u1ea1n s\u1eed d\u1ee5ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c n\u1edbi r\u1ed9ng ra th\u00eam 1 n\u0103m so v\u1edbi ng\u00e0y h\u1ebft h\u1ea1n s\u1eed d\u1ee5ng th\u00f4ng th\u01b0\u1eddng (trung b\u00ecnh s\u1ed1 ng\u00e0y m\u1edf r\u1ed9ng sau ng\u00e0y h\u1ebft h\u1ea1n ch\u00ednh th\u1ee9c tr\u00ean bao b\u00e0i l\u00e0 66 th\u00e1ng). Trong SLEP, nhi\u1ec1u kh\u00e1ng sinh nh\u01b0 ciprofloxacin, amoxicillin v\u00e0 doxycycline c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m6.<\/p>\n\n\n\n

    N\u1ebfu thu\u1ed1c kh\u00f4ng \u1edf d\u1ea1ng vi\u00ean n\u00e9n?<\/h2>\n\n\n\n

    Nhi\u1ec1u b\u1ec7nh nh\u00e2n th\u01b0\u1eddng th\u1eafc m\u1eafc v\u1ec1 tu\u1ed5i th\u1ecd c\u1ee7a c\u00e1c d\u1ea1ng b\u00e0o ch\u1ebf kh\u00e1c d\u1ea1ng vi\u00ean n\u00e9n. Thu\u1ed1c nh\u1ecf m\u1eaft l\u00e0 m\u1ed9t v\u00ed d\u1ee5. M\u1ed9t v\u00e0i d\u1eef li\u1ec7u \u0111\u00e3 cho th\u1ea5y thu\u1ed1c nh\u1ecf m\u1eaft ch\u1ee9a travoprost \u0111\u00e3 h\u1ebft h\u1ea1n s\u1eed d\u1ee5ng c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n7. Thu\u1ed1c nh\u1ecf m\u1eaft c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng truy\u1ec1n nhi\u1ec5m vi sinh v\u00e0 g\u00e2y k\u00edch \u1ee9ng2.<\/p>\n\n\n\n

    Ngo\u00e0i ra, b\u1ec7nh nh\u00e2n c\u0169ng th\u01b0\u1eddng \u0111\u1eb7t c\u00e2u h\u1ecfi v\u1ec1 thu\u1ed1c kh\u00ed dung h\u1ebft h\u1ea1n. M\u1ed9t nghi\u00ean c\u1ee9u cho th\u1ea5y albuterol c\u00f3 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh t\u1ed1t [8]. C\u1ee5 th\u1ec3, nghi\u00ean c\u1ee9u c\u1ea3u Kutty v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 cho th\u1ea5y albuteron v\u1eabn duy tr\u00ec \u0111\u01b0\u1ee3c n\u1ed3ng \u0111\u1ed9 > 90% so v\u1edbi nh\u00e3n trong v\u00f2ng 20 n\u0103m sau khi h\u1ebft h\u1ea1n 8, 9.<\/p>\n\n\n\n

    \n\n\n\n

    T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h3>\n\n\n\n
      \n
    1. Expiration Dates – Questions and Answers Share Tweet Email.https:\/\/www.fda.gov\/drugs\/pharmaceutical-quality-resources\/expiration-dates-questions-and-answers#:~<\/li>\n\n\n\n
    2. Douglas S. Paauw. More on Using Expired Medications. Medscape. Updated 02 Oct 2023. Accessedd date 10 Oct 2023.<\/li>\n\n\n\n
    3. Weir WB et al. Prehosp Emerg Care. 2018 Jul-Aug;22(4):414-8.<\/li>\n\n\n\n
    4. Rachid O et al. Ann Allergy Asthma Immunol. 2015 Apr;114(4):354-6.<\/li>\n\n\n\n
    5. Cantrell FL et al. Ann Intern Med. 2017 Jun 20;166(12):918-9.<\/li>\n\n\n\n
    6. Lyon RC et al. J Pharmaceut Sci. 2006;95(7):1549-60.<\/li>\n\n\n\n
    7. Reis R et al. Clin Ther. 2004 Dec;26(12):2121-7.<\/li>\n\n\n\n
    8. AlGhadeer H, AlHumaiden A. J Clin Pharm Ther. 2022 Dec;47(12):2379-82.<\/li>\n\n\n\n
    9. Kutty RG et al. Heliyon. 2022 Aug 5;8(8):e10104.<\/li>\n<\/ol>\n\n\n\n

      Th\u1ea3o lu\u1eadn c\u00f9ng c\u00e1c b\u00e1c s\u0129 gi\u1ecfi nh\u1ea5t trong khu v\u1ef1c. T\u00ecm hi\u1ec3u n\u1ed9i dung y khoa v\u00e0 tham d\u1ef1 c\u00e1c ch\u01b0\u01a1ng tr\u00ecnh \u0111\u00e0o t\u1ea1o \u0111\u01b0\u1ee3c c\u00e1c chuy\u00ean gia \u0111\u1ea7u ng\u00e0nh x\u00e2y d\u1ef1ng. Tham gia c\u00e1c bu\u1ed5i th\u1ea3o lu\u1eadn tr\u1ef1c tuy\u1ebfn c\u00f9ng c\u00e1c chuy\u00ean gia qu\u1ed1c t\u1ebf Docquity<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

      T\u00ecnh hu\u1ed1ng M\u1ed9t b\u1ec7nh nh\u00e2n h\u1ecfi b\u1ea1n li\u1ec7u r\u1eb1ng b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng b\u00fat ti\u00eam adrenaline \u0111\u00e3 h\u1ebft h\u1ea1n. B\u1ea1n s\u1ebd t\u01b0 v\u1ea5n th\u1ebf n\u00e0o? L\u1ef1a ch\u1ecdn C \u0111\u01b0\u1ee3c xem nh\u01b0 l\u00e0 l\u1ef1a ch\u1ecdn ch\u00ednh x\u00e1c nh\u1ea5t. Ng\u00e0y h\u1ebft h\u1ea1n kh\u00f4ng ph\u1ea3i l\u00e0 ng\u00e0y ho\u1ea1t ch\u1ea5t trong thu\u1ed1c kh\u00f4ng c\u00f2n hi\u1ec7u qu\u1ea3 hay …<\/p>\n

      M\u1ed9t v\u00e0i th\u00f4ng tin v\u1ec1 thu\u1ed1c h\u1ebft h\u1ea1n<\/span> Read More »<\/a><\/p>\n","protected":false},"author":123,"featured_media":12512,"comment_status":"closed","ping_status":"closed","template":"","meta":{"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"articles_categories":[1370],"articles_tags":[],"articles_topics":[1437],"articles_languages":[1375],"articles_filters":[],"class_list":["post-12367","articles","type-articles","status-publish","has-post-thumbnail","hentry","articles_categories-medical-content-vi","articles_languages-vietnamese-vi"],"_links":{"self":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/12367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles"}],"about":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/types\/articles"}],"author":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/comments?post=12367"}],"version-history":[{"count":0,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/12367\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media\/12512"}],"wp:attachment":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media?parent=12367"}],"wp:term":[{"taxonomy":"articles_categories","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_categories?post=12367"},{"taxonomy":"articles_tags","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_tags?post=12367"},{"taxonomy":"articles_topics","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_topics?post=12367"},{"taxonomy":"articles_languages","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_languages?post=12367"},{"taxonomy":"articles_filters","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_filters?post=12367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}