{"id":11991,"date":"2023-10-11T14:37:43","date_gmt":"2023-10-11T06:37:43","guid":{"rendered":"https:\/\/docquity.com\/?post_type=articles&p=11991"},"modified":"2025-02-11T13:37:19","modified_gmt":"2025-02-11T05:37:19","slug":"chat-uc-che-yeu-to-xi-hua-hen-cho-lua-chon-khang-dong-an-toan","status":"publish","type":"articles","link":"https:\/\/docquity.com\/vi\/articles\/chat-uc-che-yeu-to-xi-hua-hen-cho-lua-chon-khang-dong-an-toan\/","title":{"rendered":"Ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI: H\u1ee9a h\u1eb9n cho l\u1ef1a ch\u1ecdn kh\u00e1ng \u0111\u00f4ng an to\u00e0n?"},"content":{"rendered":"\n

M\u1ede \u0110\u1ea6U<\/strong><\/p>\n\n\n\n

Nhu c\u1ea7u v\u1ec1 m\u1ed9t l\u1ef1a ch\u1ecdn kh\u00e1ng \u0111\u00f4ng hi\u1ec7u qu\u1ea3 trong ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5, bi\u1ebfn c\u1ed1 tim m\u1ea1ch v\u00e0 thuy\u00ean t\u1eafc huy\u1ebft kh\u1ed1i nh\u01b0ng kh\u00f4ng l\u00e0m t\u0103ng c\u00f3 \u00fd ngh\u0129a nguy c\u01a1 xu\u1ea5t huy\u1ebft l\u00e0 m\u1ed9t \u0111i\u1ec1u kh\u00f4ng h\u1ec1 d\u1ec5 \u0111\u00e1p \u1ee9ng. Kh\u00e1ng \u0111\u00f4ng ho\u1ea1t \u0111\u1ed9ng d\u1ef1a tr\u00ean c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI l\u00e0 m\u1ed9t l\u0129nh v\u1ef1c ch\u01b0a \u0111\u01b0\u1ee3c t\u1eadp trung nghi\u00ean c\u1ee9u, c\u00e2u h\u1ecfi \u0111\u01b0\u1ee3c \u0111\u1eb7t ra l\u00e0 li\u1ec7u ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI c\u00f3 th\u1ec3 \u0111\u00e1p \u1ee9ng \u0111\u01b0\u1ee3c nhu c\u1ea7u \u201cthu\u1ed1c kh\u00e1ng \u0111\u00f4ng ho\u00e0n h\u1ea3o\u201d n\u00f3i tr\u00ean hay kh\u00f4ng?<\/p>\n\n\n\n

M\u1ed9t nghi\u00ean c\u1ee9u quy m\u00f4 l\u1edbn v\u1ec1 ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI \u201cAZALEA-TIMI 71\u201d \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 so s\u00e1nh \u0111\u1ed1i \u0111\u1ea7u DOAC v\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI abelacimab \u1edf b\u1ec7nh nh\u00e2n rung nh\u0129. Tuy nhi\u00ean d\u1eef li\u1ec7u c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3 c\u00f4ng b\u1ed1 (k\u1ebft qu\u1ea3 to\u00e0n di\u1ec7n s\u1ebd \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong H\u1ed9i ngh\u1ecb Tim m\u1ea1ch Th\u01b0\u1eddng ni\u00ean Hoa K\u1ef3 v\u00e0o th\u00e1ng 11 s\u1eafp t\u1edbi), tuy nhi\u00ean, v\u1edbi k\u1ebft qu\u1ea3 ban \u0111\u1ea7u c\u1ee7a AZALEA-TIMI 71, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u r\u1ea5t l\u1ea1c quan v\u1ec1 nh\u00f3m thu\u1ed1c n\u00e0y trong vi\u1ec7c l\u00e0m gi\u1ea3m nguy c\u01a1 xu\u1ea5t huy\u1ebft1, 2<\/sup>.<\/p>\n\n\n\n

\"\"H\u00ecnh 1. <\/strong>Ch\u1eb7ng \u0111\u01b0\u1eddng d\u00e0i ph\u00e1t tri\u1ec3n c\u1ee7a thu\u1ed1c kh\u00e1ng \u0111\u00f4ng<\/p>\n\n\n\n

V\u00cc SAO L\u1ea0I L\u00c0 Y\u1ebeU T\u1ed0 XI?<\/strong><\/p>\n\n\n\n

Hy v\u1ecdng ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI c\u00f3 th\u1ec3 ph\u00f2ng ng\u1eeba bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i, nh\u01b0ng l\u00e0m gi\u1ea3m nguy c\u01a1 xu\u1ea5t huy\u1ebft so v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng \u0111\u00f4ng kh\u00e1c \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh t\u1eeb th\u00e1c \u0111\u00f4ng m\u00e1u (coagulation cascade). Y\u1ebfu t\u1ed1 XI c\u00f3 v\u1ecb tr\u00ed \u0111\u1ed9c nh\u1ea5t trong th\u00e1c \u0111\u00f4ng m\u00e1u. Y\u1ebfu t\u1ed1 XI v\u1eeba quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u nh\u01b0ng l\u1ea1i kh\u00f4ng c\u00f3 vai tr\u00f2 c\u1ed1t y\u1ebfu trong kh\u1ea3 n\u0103ng s\u1eeda ch\u1eefa m\u1ea1ch m\u00e1u. Y\u1ebfu t\u1ed1 XI \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng trong khi v\u1eabn cho ph\u00e9p qu\u00e1 tr\u00ecnh c\u1ea7m m\u00e1u x\u1ea3y ra \u0111\u1ec3 ph\u00f2ng ng\u1eeba xu\u1ea5t huy\u1ebft. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u quan s\u00e1t c\u0169ng cho th\u1ea5y r\u1eb1ng b\u1ec7nh nh\u00e2n thi\u1ebfu h\u1ee5t y\u1ebfu t\u1ed1 XI c\u00f3 t\u1ef7 l\u1ec7 \u0111\u1ed9t qu\u1ef5 v\u00e0 nh\u1ed3i m\u00e1u c\u01a1 tim th\u1ea5p nh\u01b0ng kh\u00f4ng c\u00f3 t\u00ecnh tr\u1ea1ng xu\u1ea5t huy\u1ebft t\u1ef1 ph\u00e1t. Ch\u00ednh v\u00ec v\u1eady, \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c c\u00f3 tri\u1ec3n v\u1ecdng1<\/sup>.<\/p>\n\n\n\n

Qu\u00e1 tr\u00ecnh c\u1ea7m m\u00e1u l\u00e0m ng\u01b0ng ch\u1ea3y m\u00e1u khi c\u00f3 ch\u1ea5n th\u01b0\u01a1ng, trong khi \u0111\u00f3 qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng, c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9t qu\u1ef5, nh\u1ed3i m\u00e1u c\u01a1 tim hay thuy\u00ean t\u1eafc huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u. \u1ede b\u1ec7nh nh\u00e2n m\u1eafc c\u00e1c b\u1ec7nh l\u00fd c\u00f3 xu h\u01b0\u1edbng d\u1ec5 h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng nh\u01b0 rung nh\u0129, c\u00f3 s\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng gi\u1eefa 2 qu\u00e1 tr\u00ecnh c\u1ea7m m\u00e1u v\u00e0 \u0111\u00f4ng m\u00e1u. Do v\u1eady thu\u1ed1c kh\u00e1ng \u0111\u00f4ng d\u00f9ng \u0111\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 huy\u1ebft kh\u1ed1i. Trong nhi\u1ec1u n\u0103m, thu\u1ed1c kh\u00e1ng \u0111\u00f4ng c\u00f3 m\u1eb7t tr\u00ean th\u1ecb tr\u01b0\u1eddng r\u1ea5t ngh\u00e8o n\u00e0n v\u1edbi m\u1ed9t s\u1ed1 l\u1ef1a ch\u1ecdn nh\u01b0 warfarin, ch\u1ea5t \u0111\u1ed1i v\u1eadn th\u1ee5 th\u1ec3 vitamin K. Nh\u1eefng bi\u1ec7n ph\u00e1p n\u00e0y c\u00f3 hi\u1ec7u qu\u1ea3 trong ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5 nh\u01b0ng l\u1ea1i l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft, bao g\u1ed3m xu\u1ea5t huy\u1ebft n\u1ed9i s\u1ecd v\u00e0 xu\u1ea5t huy\u1ebft \u0111e d\u1ecda t\u00ednh m\u1ea1ng1<\/sup>. V\u00e0i n\u0103m tr\u1edf l\u1ea1i \u0111\u00e2y, s\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a thu\u1ed1c kh\u00e1ng \u0111\u00f4ng tr\u1ef1c ti\u1ebfp b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng (DOAC) l\u00e0 m\u1ed9t b\u01b0\u1edbc ti\u1ebfn l\u1edbn trong ch\u1eb7ng \u0111\u01b0\u1eddng ph\u00e1t tri\u1ec3n c\u1ee7a thu\u1ed1c kh\u00e1ng \u0111\u00f4ng. Nh\u1eefng thu\u1ed1c n\u00e0y c\u00f3 hi\u1ec7u qu\u1ea3 kh\u00f4ng thua k\u00e9m warfarin trong ph\u00f2ng ng\u1eeba c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch nh\u01b0ng l\u1ea1i c\u00f3 nguy c\u01a1 xu\u1ea5t huy\u1ebft th\u1ea5p h\u01a1n, \u0111\u1eb7c bi\u1ec7t l\u00e0 xu\u1ea5t huy\u1ebft n\u1ed9i s\u1ecd v\u00e0 xu\u1ea5t huy\u1ebft \u0111e d\u1ecda t\u00ednh m\u1ea1ng. Tuy nhi\u00ean, l\u00e0m gi\u1ea3m c\u00f3 \u00fd ngh\u0129a bi\u1ebfn c\u1ed1 xu\u1ea5t huy\u1ebft so v\u1edbi warfarin kh\u00f4ng \u0111\u1ed3ng ngh\u0129a v\u1edbi vi\u1ec7c kh\u00f4ng g\u00e2y xu\u1ea5t huy\u1ebft. S\u1ef1 th\u1eadt l\u00e0 h\u00e0ng tri\u1ec7u bi\u1ebfn c\u1ed1 xu\u1ea5t huy\u1ebft \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn t\u1eeb c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng DOAC1<\/sup>. Tr\u00ean th\u1ef1c t\u1ebf, nguy c\u01a1 xu\u1ea5t huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng DOAC cao g\u1ea5p 2 \u2013 3 l\u1ea7n so v\u1edbi b\u1ec7nh nh\u00e2n nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c \u0111\u1ec3 ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5. \u0110\u00e2y c\u0169ng ch\u00ednh l\u00e0 \u0111\u1ed9ng l\u1ef1c \u0111\u1ec3 vi\u1ec7c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n thu\u1ed1c kh\u00e1ng \u0111\u00f4ng r\u1ebd sang h\u01b0\u1edbng \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI 1, 2<\/sup>.<\/p>\n\n\n\n

C\u00c1C HO\u1ea0T CH\u1ea4T \u0110ANG \u0110\u01af\u1ee2C PH\u00c1T TRI\u1ec2N<\/strong><\/p>\n\n\n\n

C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI \u0111ang trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n l\u00e2m s\u00e0ng. Cho t\u1edbi nay, c\u00f3 3 ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n bao g\u1ed3m abelacimab, kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng d\u1ea1ng ti\u00eam d\u01b0\u1edbi da, li\u1ec1u d\u00f9ng 1 l\u1ea7n\/th\u00e1ng, milvexian v\u00e0 asundexian, 2 ho\u1ea1t ch\u1ea5t n\u00e0y \u0111\u1ec1u c\u00f3 d\u1ea1ng b\u00e0o ch\u1ebf \u0111\u01b0\u1eddng u\u1ed1ng1<\/sup>.<\/p>\n\n\n\n

Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha II c\u1ee7a 3 ho\u1ea1t ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI n\u00e0y \u0111\u1ec1u v\u1eeba \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean nhi\u1ec1u ch\u1ec9 \u0111\u1ecbnh, bao g\u1ed3m ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5 \u1edf b\u1ec7nh nh\u00e2n rung nh\u0129, ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5 t\u00e1i ph\u00e1t \u1edf b\u1ec7nh nh\u00e2n \u0111\u1ed9t qu\u1ef5 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 ph\u00f2ng ng\u1eeba c\u00e1c bi\u1ebfn c\u1ed1 tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n m\u1eafc h\u1ed9i ch\u1ee9ng v\u00e0nh c\u1ea5p1<\/sup>.<\/p>\n\n\n\n

Nh\u00f3m nghi\u00ean c\u1ee9u mivexian v\u00e0 asundexian cho r\u1eb1ng d\u1eef li\u1ec7u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha II c\u1ee7a 2 ho\u1ea1t ch\u1ea5t n\u00e0y \u0111\u1ec1u r\u1ea5t tri\u1ec3n v\u1ecdng. Li\u1ec1u d\u00f9ng trong c\u1eeda s\u1ed5 tr\u1ecb li\u1ec7u \u0111\u1ec3 ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5 g\u00e2y xu\u1ea5t huy\u1ebft r\u1ea5t \u00edt so v\u1edbi li\u1ec1u tr\u1ecb li\u1ec7u c\u1ee7a DOAC v\u00e0 heparin tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed th\u1ea5p1<\/sup>. Trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng AZALEA v\u1edbi abelacimab, th\u1eed nghi\u1ec7m trong ch\u01b0\u01a1ng tr\u00ecnh PACIFIC program pha II c\u0169ng cho th\u1ea5y asundexian g\u00e2y ra \u00edt bi\u1ebfn c\u1ed1 xu\u1ea5t huy\u1ebft h\u01a1n apixaban \u1edf b\u1ec7nh nh\u00e2n rung nh\u0129, v\u00e0 c\u00f3 t\u1ef7 l\u1ec7 bi\u1ebfn c\u1ed1 xu\u1ea5t huy\u1ebft t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c \u1edf b\u1ec7nh nh\u00e2n m\u1eafc h\u1ed9i ch\u1ee9ng v\u00e0nh c\u1ea5p.\u0111\u1ed9t qu\u1ef5 \u0111ang \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c kh\u00e1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u. Milvexian c\u0169ng cho th\u1ea5y k\u1ebft qu\u1ea3 t\u01b0\u01a1ng t\u1ef1 trong ch\u01b0\u01a1ng tr\u00ecnh th\u1eed nghi\u1ec7m AXIOMATIC1<\/sup>.<\/p>\n\n\n\n

TH\u1eec NGHI\u1ec6M AZALEA<\/strong><\/p>\n\n\n\n

Th\u1eed nghi\u1ec7m AZALEA \u0111\u01b0\u1ee3c cho l\u00e0 th\u1eed nghi\u1ec7m c\u00f3 quy m\u00f4 l\u1edbn nh\u1ea5t c\u1ee7a c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI cho t\u1edbi nay, bao g\u1ed3m 1287 b\u1ec7nh nh\u00e2n v\u1edbi th\u1eddi gian theo d\u00f5i trung v\u1ecb l\u00e0 2 n\u0103m. Nghi\u00ean c\u1ee9u AZALEA \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean b\u1ec7nh nh\u00e2n rung nh\u0129 c\u00f3 nguy c\u01a1 \u0111\u1ed9t qu\u1ef5 trung b\u00ecnh \u2013 cao. B\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean theo t\u1ef7 l\u1ec7 1:1:1 v\u00e0o 3 nh\u00f3m: (i) abelacimab li\u1ec1u 150 mg \u0111\u01b0\u1eddng ti\u00eam d\u01b0\u1edbi da x 1 l\u1ea7n\/th\u00e1ng; (ii) abelacimab li\u1ec1u 90 mg \u0111\u01b0\u1eddng ti\u00eam d\u01b0\u1edbi da x 1 l\u1ea7n\/th\u00e1ng v\u00e0 (iii) rivaroxaban 20 mg\/ng\u00e0y. K\u1ebft c\u1ee5c ch\u00ednh c\u1ee7a nghi\u00ean c\u1ee9u l\u00e0 ti\u00eau ch\u00ed an to\u00e0n \u0111\u00e1nh gi\u00e1 d\u1ef1a tr\u00ean c\u00e1c bi\u1ebfn c\u1ed1 xu\u1ea5t huy\u1ebft nghi\u00eam tr\u1ecdng ho\u1eb7c kh\u00f4ng nghi\u00eam tr\u1ecdng li\u00ean quan v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng2<\/sup>. Tuy d\u1eef li\u1ec7u c\u1ee7a nghi\u00ean c\u1ee9u ch\u01b0a \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1, nh\u01b0ng theo th\u00f4ng tin ban \u0111\u1ea7u m\u00e0 nh\u00f3m nghi\u00ean c\u1ee9u cung c\u1ea5p, AZALEA l\u00e0 th\u1eed nghi\u1ec7m \u0111\u1ed1i \u0111\u1ea7u \u0111\u1ea7u ti\u00ean gi\u1eefa ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI v\u00e0 DOAC trong th\u1eddi gian d\u00e0i theo d\u00f5i, th\u1eed nghi\u1ec7m \u0111\u00e3 \u0111\u01b0\u1ee3c k\u1ebft th\u00fac v\u00ec l\u1ee3i \u00edch r\u00f5 r\u1ec7t c\u1ee7a abelacimab so v\u1edbi rivaroxaban 1<\/sup>.<\/p>\n\n\n\n

\"\"H\u00ecnh 2.<\/strong> T\u00f3m t\u1eaft nghi\u00ean c\u1ee9u AZALEA-TIMI 71<\/p>\n\n\n\n

S\u1ef0 KH\u00c1C BI\u1ec6T GI\u1eeeA 3 HO\u1ea0T CH\u1ea4T \u1ee8C CH\u1ebe Y\u1ebeU T\u1ed0 XI<\/strong><\/p>\n\n\n\n

Abelacimab \u2013 m\u1ed9t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng c\u00f3 th\u1ec3 mang \u0111\u1ebfn hi\u1ec7u l\u1ef1c \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI m\u1ea1nh m\u1ebd h\u01a1n milvexian v\u00e0 asundexian. Ngo\u00e0i ra, d\u1ea1ng b\u00e0o ch\u1ebf v\u00e0 ch\u1ebf \u0111\u1ed9 li\u1ec1u c\u1ee7a 3 t\u00e1c nh\u00e2n n\u00e0y c\u0169ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t. Abelacimab c\u00f3 \u0111\u01b0\u1eddng ti\u00eam d\u01b0\u1edbi da v\u1edbi ch\u1ebf \u0111\u1ed9 li\u1ec1u 1 l\u1ea7n\/th\u00e1ng do c\u00f3 th\u1eddi gian t\u00e1c \u0111\u1ed9ng k\u00e9o d\u00e0i, milvexian v\u00e0 asundexian \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf d\u01b0\u1edbi d\u1ea1ng \u0111\u01b0\u1eddng u\u1ed1ng 1 l\u1ea7n\/ng\u00e0y do c\u00f3 th\u1eddi gian t\u00e1c \u0111\u1ed9ng ng\u1eafn h\u01a1n. \u0110\u1ed1i v\u1edbi nh\u1eefng thu\u1ed1c c\u00f3 nguy c\u01a1 xu\u1ea5t huy\u1ebft cao, thu\u1ed1c c\u00f3 th\u1eddi gian t\u00e1c \u0111\u1ed9ng k\u00e9o d\u00e0i nh\u01b0 abelacimab kh\u00f4ng th\u1ef1c s\u1ef1 l\u00e0 m\u1ed9t l\u1ee3i th\u1ec3 v\u00ec kh\u00f4ng th\u1ec3 ng\u0103n ch\u1eb7n xu\u1ea5t huy\u1ebft. Tuy nhi\u00ean cho \u0111\u1ebfn nay, d\u1eef li\u1ec7u lu\u00f4n cho th\u1ea5y abelacimab an to\u00e0n v\u00e0 kh\u00f4ng l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft. V\u1edbi ch\u1ebf \u0111\u1ed9 li\u1ec1u 1 l\u1ea7n\/th\u00e1ng, abelacimab c\u00f3 th\u1ec3 c\u1ea3i thi\u1ec7n s\u1ef1 tu\u00e2n th\u1ee7 \u0111i\u1ec1u tr\u1ecb – m\u1ed9t y\u1ebfu t\u1ed1 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 \u0111\u1ed9t qu\u1ef5 cao v\u00e0 c\u00f3 nhi\u1ec1u thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh m\u1eafc k\u00e8m1<\/sup>.<\/p>\n\n\n\n

\u1ea2NH H\u01af\u1edeNG TR\u00caN L\u00c2M S\u00c0NG C\u1ee6A CH\u1ea4T \u1ee8C CH\u1ebe Y\u1ebeU T\u1ed0 XI<\/strong><\/p>\n\n\n\n

N\u1ebfu th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha III cho th\u1ea5y hi\u1ec7u l\u1ef1c c\u1ee7a ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI, ti\u1ec1m n\u0103ng \u1ee9ng d\u1ee5ng c\u1ee7a nh\u1eefng ch\u1ea5t n\u00e0y tr\u00ean l\u00e2m s\u00e0ng l\u00e0 r\u1ea5t l\u1edbn. N\u1ebfu hi\u1ec7u l\u1ef1c c\u1ee7a ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI kh\u00f4ng thua k\u00e9m DOAC trong ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5, c\u00f9ng v\u1edbi h\u1ed3 s\u01a1 an to\u00e0n v\u01b0\u1ee3t tr\u1ed9i, kh\u1ea3 n\u0103ng ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI c\u00f3 th\u1ec3 thay th\u1ebf DOAC l\u00e0 r\u1ea5t l\u1edbn. Ng\u01b0\u1ee3c l\u1ea1i, n\u1ebfu ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI c\u00f3 hi\u1ec7u l\u1ef1c thua k\u00e9m DOAC, th\u00ec ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI v\u1eabn c\u00f3 th\u1ec3 c\u00f3 vai tr\u00f2 trong l\u00e2m s\u00e0ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng kh\u00e1ng \u0111\u00f4ng do nh\u1eefng lo ng\u1ea1i v\u1ec1 bi\u1ebfn c\u1ed1 xu\u1ea5t huy\u1ebft.<\/p>\n\n\n\n

\u0110\u1ed1i v\u1edbi v\u1ea5n \u0111\u1ec1 gi\u00e1 c\u1ea3, m\u1ed9t v\u1ea5n \u0111\u1ec1 hi\u1ec3n nhi\u00ean t\u1ed3n \u0111\u1ecdng \u0111\u00f3 l\u00e0 thu\u1ed1c m\u1edbi th\u01b0\u1eddng c\u00f3 chi ph\u00ed r\u1ea5t cao. Trong khi DOAC b\u1eaft \u0111\u1ea7u c\u00f3 generic v\u1edbi chi ph\u00ed th\u1ea5p h\u01a1n, th\u00ec c\u00f3 th\u1ec3 kh\u00f4ng ph\u1ea3i b\u1ec7nh nh\u00e2n n\u00e0o c\u0169ng c\u00f3 th\u1ec3 ti\u1ebfp c\u1eadn ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI.<\/p>\n\n\n\n

B\u00c0N LU\u1eacN<\/strong><\/p>\n\n\n\n

Cho \u0111\u1ebfn nay, hi\u1ec7u l\u1ef1c v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf y\u1ebfu t\u1ed1 XI \u1edf b\u1ec7nh nh\u00e2n rung nh\u0129 v\u1eabn c\u00f2n l\u00e0 m\u1ed9t \u1ea9n s\u1ed1 v\u00ec c\u00e1c d\u1eef li\u1ec7u nghi\u00ean c\u1ee9u v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1. Ch\u00fang t\u00f4i s\u1ebd lu\u00f4n c\u1eadp nh\u1eadt \u0111\u1ebfn qu\u00fd v\u1ecb \u0111\u1ed9c gi\u1ea3 tin t\u1ee9c v\u1ec1 nh\u00f3m thu\u1ed1c m\u1edbi n\u00e0y, \u0111\u1eb7c bi\u1ec7t l\u00e0 phi\u00ean b\u00e1o c\u00e1o li\u00ean quan trong H\u1ed9i ngh\u1ecb T\u1ecbm m\u1ea1ch Hoa K\u1ef3 s\u1eafp t\u1edbi v\u00e0o th\u00e1ng 11.<\/p>\n\n\n\n

\n\n\n\n

T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/p>\n\n\n\n

    \n
  1. Sue Hughes. Factor XI Inhibitors: The Promise of a Truly Safe Anticoagulant? Medscape. Updated 28 Sep 2023. Accessed date 29 Sep 2023. URL: https:\/\/www.medscape.com\/viewarticle\/996923?src=<\/li>\n\n\n\n
  2. TIMI STUDY GROUP. AZALEA-TIMI 71. Accessed date 1 Oct 2023. URL: https:\/\/timi.org\/azalea-timi-71\/<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    M\u1ede \u0110\u1ea6U Nhu c\u1ea7u v\u1ec1 m\u1ed9t l\u1ef1a ch\u1ecdn kh\u00e1ng \u0111\u00f4ng hi\u1ec7u qu\u1ea3 trong ph\u00f2ng ng\u1eeba \u0111\u1ed9t qu\u1ef5, bi\u1ebfn c\u1ed1 tim m\u1ea1ch v\u00e0 thuy\u00ean t\u1eafc huy\u1ebft kh\u1ed1i nh\u01b0ng kh\u00f4ng l\u00e0m t\u0103ng c\u00f3 \u00fd ngh\u0129a nguy c\u01a1 xu\u1ea5t huy\u1ebft l\u00e0 m\u1ed9t \u0111i\u1ec1u kh\u00f4ng h\u1ec1 d\u1ec5 \u0111\u00e1p \u1ee9ng. Kh\u00e1ng \u0111\u00f4ng ho\u1ea1t \u0111\u1ed9ng d\u1ef1a tr\u00ean c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf …<\/p>\n

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