{"id":10834,"date":"2023-08-02T23:56:44","date_gmt":"2023-08-02T15:56:44","guid":{"rendered":"https:\/\/docquity.com\/?post_type=articles&#038;p=10834"},"modified":"2025-02-11T13:36:21","modified_gmt":"2025-02-11T05:36:21","slug":"hoi-nghi-ada-2023-retatrutide-giam-duoc-muc-can-nang-ky-luc","status":"publish","type":"articles","link":"https:\/\/docquity.com\/vi\/articles\/hoi-nghi-ada-2023-retatrutide-giam-duoc-muc-can-nang-ky-luc\/","title":{"rendered":"H\u1ed9i ngh\u1ecb ADA 2023: Retatrutide gi\u1ea3m \u0111\u01b0\u1ee3c m\u1ee9c c\u00e2n n\u1eb7ng k\u1ef7 l\u1ee5c"},"content":{"rendered":"\n<p><strong>M\u1ede \u0110\u1ea6U<\/strong><\/p>\n\n\n\n<p>T\u1eeb ng\u00e0y 23 \u2013 26 th\u00e1ng 06 v\u1eeba qua, H\u1ed9i ngh\u1ecb Khoa h\u1ecdc Th\u01b0\u1eddng ni\u00ean l\u1ea7n th\u1ee9 83 c\u1ee7a Hi\u1ec7p h\u1ed9i \u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng Hoa K\u1ef3 (ADA) \u0111\u00e3 di\u1ec5n ra t\u1ea1i San Diego. H\u1ed9i ngh\u1ecb \u0111\u00e3 mang \u0111\u1ebfn nhi\u1ec1u th\u00f4ng tin v\u00e0 b\u1eb1ng ch\u1ee9ng y khoa m\u1edbi trong ki\u1ec3m so\u00e1t b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng. Trong \u0111\u00f3, k\u1ebft qu\u1ea3 c\u1ee7a 2 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha 2, ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng, m\u00f9 \u0111\u00f4i \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 gi\u1ea3m c\u00e2n c\u1ee7a retatrutide \u2013 m\u1ed9t ch\u1ea5t ch\u1ee7 v\u1eadn \u0111\u1ed3ng th\u1eddi c\u1ee7a glucose-dependent insulinotropic polypeptide (GIP), th\u1ee5 th\u1ec3 glucagon-like peptide-1 (GLP-1) v\u00e0 th\u1ee5 th\u1ec3 glucagon \u0111\u00e3 thu h\u00fat \u0111\u01b0\u1ee3c nhi\u1ec1u s\u1ef1 ch\u00fa \u00fd, tr\u1edf th\u00e0nh t\u00e2m \u0111i\u1ec3m n\u1ed5i b\u1eadt h\u00e0ng \u0111\u1ea7u trong h\u1ed9i ngh\u1ecb.<\/p>\n\n\n\n<p>B\u00e0i vi\u1ebft nh\u1eb1m t\u00f3m t\u1eaft phi\u00ean b\u00e1o c\u00e1o \u0111\u1ebfn b\u1ea1n \u0111\u1ecdc.<\/p>\n\n\n\n<p><strong>T\u00d3M T\u1eaeT N\u1ed8I DUNG B\u00c1O C\u00c1O<\/strong><\/p>\n\n\n\n<p>K\u1ebft qu\u1ea3 c\u1ee7a 2 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho th\u1ea5y retatrutide \u2013 m\u1ed9t thu\u1ed1c ch\u1ee7 v\u1eadn \u0111\u1ed3ng th\u1eddi GIP, GLP-1 v\u00e0 th\u1ee5 th\u1ec3 glucagon \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong h\u1ed9i ngh\u1ecb khoa h\u1ecdc l\u1ea7n th\u1ee9 83 c\u1ee7a ADA. Hi\u1ec7u qu\u1ea3 gi\u1ea3m c\u00e2n c\u1ee7a retatrutide \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 qua 2 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean b\u1ec7nh nh\u00e2n b\u00e9o ph\u00ec, c\u00f3 nghi\u00ean c\u1ee9u ph\u00e2n nh\u00f3m \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh gan nhi\u1ec5m m\u1ee1 do r\u01b0\u1ee3u<\/li>\n\n\n\n<li>Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 [1].<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/s3-ap-southeast-1.amazonaws.com\/bucket.docquity.com\/journals\/editor\/file-f606e8390c3c21c4af91fca45ea135b2.png\" alt=\"\" \/><\/figure>\n\n\n\n<p><strong>Th\u1eed nghi\u1ec7m v\u1ec1 ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb b\u00e9o ph\u00ec c\u1ee7a retatrutide<\/strong><\/p>\n\n\n\n<p>Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu 2, ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh nh\u1eb1m \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a retatrutide \u1edf b\u1ec7nh nh\u00e2n b\u00e9o ph\u00ec. Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed danh ti\u1ebfng&nbsp;<em>The New England Journal of Medicine<\/em>&nbsp;v\u00e0o th\u00e1ng 06\/2023 [2].<\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean 338 b\u1ec7nh nh\u00e2n b\u00e9o ph\u00ec v\u1edbi BMI \u2265 30 ho\u1eb7c c\u00f3 BMI n\u1eb1m trong kho\u1ea3ng 27 \u2013 30 m\u1eafc k\u00e8m m\u1ed9t b\u1ec7nh l\u00fd li\u00ean quan \u0111\u1ebfn c\u00e2n n\u1eb7ng, kh\u00f4ng m\u1eafc k\u00e8m \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng. Nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean theo t\u1ef7 l\u1ec7 2:1:1:1:1:2:2 \u0111\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng retatrutide \u0111\u01b0\u1eddng ti\u00eam d\u01b0\u1edbi da (x 1 l\u1ea7n\/tu\u1ea7n) v\u1edbi 6 li\u1ec1u\/ch\u1ebf \u0111\u1ed9 li\u1ec1u kh\u00e1c nhau: (i) 1 mg; (ii) li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg r\u1ed3i sau \u0111\u00f3 4 mg; (iii) 4 mg; (iv) li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg r\u1ed3i 8 mg; (v) li\u1ec1u kh\u1edfi \u0111\u1ea7u 4 mg r\u1ed3i 8 mg; (vi) li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg r\u1ed3i 12 mg v\u00e0 gi\u1ea3 d\u01b0\u1ee3c trong v\u00f2ng 48 tu\u1ea7n [2].<\/p>\n\n\n\n<p>Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ch\u00ednh c\u1ee7a nghi\u00ean c\u1ee9u l\u00e0 t\u1ef7 l\u1ec7 c\u00e2n n\u1eb7ng thay \u0111\u1ed5i sau 24 tu\u1ea7n so v\u1edbi c\u00e2n n\u1eb7ng ban \u0111\u1ea7u. Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ph\u1ee5 l\u00e0 t\u1ef7 l\u1ec7 c\u00e2n n\u1eb7ng thay \u0111\u1ed5i sau 48 tu\u1ea7n so v\u1edbi c\u00e2n n\u1eb7ng ban \u0111\u1ea7u v\u00e0 t\u1ef7 l\u1ec7 c\u00e2n n\u1eb7ng thay \u0111\u1ed5i \u2265 5%, \u2265 10% hay \u2265 15%. H\u1ed3 s\u01a1 an to\u00e0n c\u1ee7a retatrutide c\u0169ng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 [2].<\/p>\n\n\n\n<p>Khi so s\u00e1nh b\u00ecnh ph\u01b0\u01a1ng t\u1ed1i thi\u1ec3u c\u1ee7a ph\u1ea7n tr\u0103m c\u00e2n n\u1eb7ng thay \u0111\u1ed5i, k\u1ebft qu\u1ea3 cho th\u1ea5y trong v\u00f2ng 24 tu\u1ea7n, b\u1ec7nh nh\u00e2n \u1edf nh\u00f3m \u0111i\u1ec1u tr\u1ecb b\u1eb1ng retatrutide li\u1ec1u 1 mg gi\u1ea3m \u0111\u01b0\u1ee3c 7.2% c\u00e2n n\u1eb7ng, li\u1ec1u 4 mg gi\u1ea3m \u0111\u01b0\u1ee3c 12.9% c\u00e2n n\u1eb7ng, li\u1ec1u 8 mg gi\u1ea3m \u0111\u01b0\u1ee3c 17.3% c\u00e2n n\u1eb7ng v\u00e0 li\u1ec1u 12 mg gi\u1ea3m \u0111\u01b0\u1ee3c 17.5% c\u00e2n n\u1eb7ng. Trong khi \u0111\u00f3 nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c ch\u1ec9 gi\u1ea3m \u0111\u01b0\u1ee3c 1.6% c\u00e2n n\u1eb7ng. Trong v\u00f2ng 48 tu\u1ea7n, nh\u00f3m \u0111i\u1ec1u tr\u1ecb v\u1edbi retatrutide li\u1ec1u 1 mg gi\u1ea3m \u0111\u01b0\u1ee3c 8.7% c\u00e2n n\u1eb7ng, li\u1ec1u 4 mg gi\u1ea3m \u0111\u01b0\u1ee3c 17.1% c\u00e2n n\u1eb7ng, li\u1ec1u 8 mg gi\u1ea3m \u0111\u01b0\u1ee3c 22.8% c\u00e2n n\u1eb7ng v\u00e0 li\u1ec1u 12 mg gi\u1ea3m \u0111\u01b0\u1ee3c 24.2% c\u00e2n n\u1eb7ng. Nh\u00f3m \u0111i\u1ec1u tr\u1ecb v\u1edbi gi\u1ea3 d\u01b0\u1ee3c gi\u1ea3m \u0111\u01b0\u1ee3c 2.1% c\u00e2n n\u1eb7ng. Nh\u01b0 v\u1eady, retatrutide li\u1ec1u cao nh\u1ea5t (li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg sau \u0111\u00f3 12 mg) c\u00f3 hi\u1ec7u l\u1ef1c gi\u1ea3m c\u00e2n m\u1ea1nh nh\u1ea5t trong t\u1ea5t c\u1ea3 c\u00e1c ch\u1ebf \u0111\u1ed9 li\u1ec1u. T\u1ea1i tu\u1ea7n th\u1ee9 48, t\u1ef7 l\u1ec7 ng\u01b0\u1eddi tham gia nghi\u00ean c\u1ee9u gi\u1ea3m \u0111\u01b0\u1ee3c \u2265 5% c\u00e2n n\u1eb7ng, \u2265 10% c\u00e2n n\u1eb7ng v\u00e0 \u2265 15% c\u00e2n n\u1eb7ng l\u1ea7n l\u01b0\u1ee3t l\u00e0 92%, 75% v\u00e0 60% \u0111\u1ed1i v\u1edbi nh\u00f3m li\u1ec1u 4 mg retatrutide; 100%, 91% v\u00e0 75% \u1edf nh\u00f3m li\u1ec1u 8 mg v\u00e0 100%, 93% v\u00e0 83% \u1edf nh\u00f3m li\u1ec1u 12 mg. T\u1ef7 l\u1ec7 n\u00e0y \u1edf nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c l\u00e0 27%, 9% v\u00e0 2% [2].<\/p>\n\n\n\n<p>Bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i ph\u1ed5 bi\u1ebfn \u1edf nh\u00f3m \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng retatrutide bao g\u1ed3m c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a (ph\u1ee5 thu\u1ed9c li\u1ec1u), m\u1ee9c \u0111\u1ed9 nh\u1eb9 &#8211; trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng. Nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u1ea5p h\u01a1n (kh\u1edfi \u0111\u1ea7u v\u1edbi li\u1ec1u 2 mg) g\u1eb7p c\u00e1c bi\u1ebfn c\u1ed1 tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a \u00edt nghi\u00eam tr\u1ecdng h\u01a1n so v\u1edbi nh\u00f3m \u0111i\u1ec1u tr\u1ecb kh\u1edfi \u0111\u1ea7u v\u1edbi li\u1ec1u cao h\u01a1n (4 mg). T\u1ea7n s\u1ed1 tim t\u0103ng ph\u1ee5 thu\u1ed9c li\u1ec1u \u0111\u1ea1t \u0111\u1ec9nh \u1edf tu\u1ea7n 24 v\u00e0 sau \u0111\u00f3 gi\u1ea3m [2].<\/p>\n\n\n\n<p><strong>Th\u1eed nghi\u1ec7m tr\u00ean b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u1ee7a retatrutide<\/strong><\/p>\n\n\n\n<p>Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh nh\u1eb1m \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u01b0c v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a retatrutide trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng trong h\u01a1n 36 tu\u1ea7n. Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed&nbsp;<em>The Lancet&nbsp;<\/em>v\u00e0o th\u00e1ng 06\/2023. Nghi\u00ean c\u1ee9u bao g\u1ed3m 281 b\u1ec7nh nh\u00e2n m\u1eafc \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 (tu\u1ed5i trung b\u00ecnh 56.2, s\u1ed1 n\u0103m m\u1eafc \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng trung b\u00ecnh 8.1 n\u0103m). Nh\u1eefng b\u1ec7nh nh\u00e2n tham gia nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean theo t\u1ef7 l\u1ec7 2:2:2:1:1:1:1:2 v\u00e0o c\u00e1c nh\u00f3m \u0111i\u1ec1u tr\u1ecb v\u1edbi retatrutide \u0111\u01b0\u1eddng ti\u00eam (x 1 l\u1ea7n\/tu\u1ea7n) li\u1ec1u (i) 0.5 mg; (ii) li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg r\u1ed3i 4 mg; (iii) 4 mg; (iv) li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg r\u1ed3i 8 mg; (v) li\u1ec1u kh\u1edfi \u0111\u1ea7u 4 mg r\u1ed3i 8 mg ho\u1eb7c (vi) li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg r\u1ed3i 12 mg; v\u1edbi dulaglutide li\u1ec1u 1.5 mg ho\u1eb7c v\u1edbi gi\u1ea3 d\u01b0\u1ee3c [3].<\/p>\n\n\n\n<p>Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ch\u00ednh bao g\u1ed3m thay \u0111\u1ed5i HbA1c \u1edf th\u1eddi \u0111i\u1ec3m tu\u1ea7n 24 so v\u1edbi HbA1c ban \u0111\u1ea7u. Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ph\u1ee5 bao g\u1ed3m thay \u0111\u1ed5i HbA1c v\u00e0 c\u00e2n n\u1eb7ng \u1edf th\u1eddi \u0111i\u1ec3m tu\u1ea7n 36 so v\u1edbi nh\u1eefng th\u00f4ng s\u1ed1 ban \u0111\u1ea7u. H\u1ed3 s\u01a1 an to\u00e0n c\u1ee7a retatrutide c\u0169ng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 [3].<\/p>\n\n\n\n<p>Khi so s\u00e1nh b\u00ecnh ph\u01b0\u01a1ng t\u1ed1i thi\u1ec3u c\u1ee7a ph\u1ea7n tr\u0103m HbA1c thay \u0111\u1ed5i, t\u1ea1i tu\u1ea7n th\u1ee9 24, HbA1c gi\u1ea3m \u0111\u01b0\u1ee3c 0.43% \u1edf nh\u00f3m retatrutide 0.5 mg. Nh\u00f3m 4mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg) gi\u1ea3m 1.39%, nh\u00f3m 4 mg gi\u1ea3m 1.30%, nh\u00f3m 8 mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg) gi\u1ea3m 1.99%, nh\u00f3m 8 mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 4 mg) gi\u1ea3m 1.88% v\u00e0 nh\u00f3m 12 mg (li\u1ec1u kh\u1edfi \u0111\u00e0u 2 mg) gi\u1ea3m 2.02%. Nh\u00f3m \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng dulaglutide gi\u1ea3m 1.41% v\u00e0 nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c gi\u1ea3m 0.01%. Retatrutide gi\u1ea3m HbA1c nhi\u1ec1u h\u01a1n c\u00f3 \u00fd ngh\u0129a so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c \u1edf m\u1ecdi ch\u1ebf \u0111\u1ed9 li\u1ec1u ngo\u1ea1i tr\u1eeb li\u1ec1u 0.5 mg. So v\u1edbi dulaglutide 1.5 mg, retatrutide gi\u1ea3m HbA1c nhi\u1ec1u h\u01a1n c\u00f3 \u00fd ngh\u0129a \u1edf ch\u1ebf \u0111\u1ed9 li\u1ec1u 8 mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg) v\u00e0 li\u1ec1u 12 mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg). K\u1ebft qu\u1ea3 t\u01b0\u01a1ng t\u1ef1 \u1edf tu\u1ea7n th\u1ee9 36. X\u00e9t \u0111\u1ebfn hi\u1ec7u l\u1ef1c thay \u0111\u1ed5i c\u00e2n n\u1eb7ng, retatrutide li\u1ec1u 0.5 mg gi\u1ea3m \u0111\u01b0\u1ee3c 3.19% c\u00e2n n\u1eb7ng, li\u1ec1u 4 mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg) gi\u1ea3m \u0111\u01b0\u1ee3c 7.92% c\u00e2n n\u1eb7ng, li\u1ec1u 4 mg gi\u1ea3m 10.37% c\u00e2n n\u1eb7ng, li\u1ec1u 8 mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg) gi\u1ea3m 16.81% c\u00e2n n\u1eb7ng, li\u1ec1u 8 mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 4 mg) gi\u1ea3m 16.34% c\u00e2n n\u1eb7ng v\u00e0 li\u1ec1u 12 mg (li\u1ec1u kh\u1edfi \u0111\u1ea7u 2 mg) gi\u1ea3m 16.94% c\u00e2n n\u1eb7ng t\u1ea1i tu\u1ea7n th\u1ee9 36. Dulaglutide li\u1ec1u 1.5 mg gi\u1ea3m \u0111\u01b0\u1ee3c 2.02% c\u00e2n n\u1eb7ng v\u00e0 gi\u1ea3 d\u01b0\u1ee3c gi\u1ea3m \u0111\u01b0\u1ee3c 3.00% c\u00e2n n\u1eb7ng. Retatrutide v\u1edbi li\u1ec1u \u2265 4 mg gi\u1ea3m c\u00e2n nhi\u1ec1u h\u01a1n c\u00f3 \u00fd ngh\u0129a so v\u1edbi c\u1ea3 gi\u1ea3 d\u01b0\u1ee3c v\u00e0 dulaglutide 1.5 mg [3].<\/p>\n\n\n\n<p>Bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i ghi nh\u1eadn \u0111\u01b0\u1ee3c \u1edf nh\u00f3m \u0111i\u1ec1u tr\u1ecb v\u1edbi retatrutide bao g\u1ed3m n\u00f4n, ti\u00eau ch\u1ea3y, n\u00f4n v\u00e0 t\u00e1o b\u00f3n. Kh\u00f4ng c\u00f3 bi\u1ebfn c\u1ed1 h\u1ea1 huy\u1ebft \u00e1p nghi\u00eam tr\u1ecdng n\u00e0o \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong qu\u00e1 tr\u00ecnh theo d\u00f5i [3].<\/p>\n\n\n\n<p>Nh\u01b0 v\u1eady, sau 36 tu\u1ea7n theo d\u00f5i, retatrutide cho th\u1ea5y kh\u1ea3 n\u0103ng c\u1ea3i thi\u1ec7n c\u00f3 \u00fd ngh\u0129a \u0111\u01b0\u1eddng huy\u1ebft v\u00e0 c\u00e2n n\u1eb7ng \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng [3].<\/p>\n\n\n\n<p><strong>B\u00c0N LU\u1eacN<\/strong><\/p>\n\n\n\n<p>C\u00f3 th\u1ec3 cho r\u1eb1ng \u0111\u00e2y l\u00e0 s\u1ed1 c\u00e2n n\u1eb7ng gi\u1ea3m \u0111\u01b0\u1ee3c k\u1ef7 l\u1ee5c b\u1eb1ng thu\u1ed1c ch\u1ec9 sau g\u1ea7n 1 n\u0103m \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c ghi nh\u1eadn [4]. Kh\u00f4ng nh\u1eefng v\u1eady, s\u1ed1 l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n \u0111\u01b0a \u0111\u01b0\u1ee3c \u0111\u01b0\u1eddng huy\u1ebft tr\u1edf v\u1ec1 m\u1ee9c b\u00ecnh th\u01b0\u1eddng trong nghi\u00ean c\u1ee9u c\u0169ng l\u00e0 m\u1ed9t con s\u1ed1 \u0111\u00e1ng kinh ng\u1ea1c [4]. Retatrutide \u0111\u00e3 m\u1edf ra m\u1ed9t hy v\u1ecdng m\u1edbi trong ki\u1ec3m so\u00e1t b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, b\u1ec7nh nh\u00e2n b\u00e9o ph\u00ec v\u00e0 b\u1ec7nh nh\u00e2n m\u1eafc \u0111\u1ed3ng th\u1eddi c\u1ea3 2 b\u1ec7nh l\u00fd.<\/p>\n\n\n\n<p>Hi\u1ec7u l\u1ef1c v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a retatrutide trong ki\u1ec3m so\u00e1t c\u00e2n n\u1eb7ng, ng\u01b0ng th\u1edf t\u1eafc ngh\u1ebdn khi ng\u1ee7, tho\u00e1i h\u00f3a kh\u1edbp \u1edf b\u1ec7nh nh\u00e2n b\u00e9o ph\u00ec v\u00e0 th\u1eeba c\u00e2n s\u1ebd \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha 3, ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p><strong>T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Press release. American Diabetes Association Highlights Novel Agent Retatrutide which Results in Substantial Weight Reduction in People with Obesity or Type 2 Diabetes During Late Breaking Symposium. American Diabetes Associations. Updated 26 Jun 2023. Accessed date 05 Jun 2023. URL: https:\/\/diabetes.org\/newsroom\/press-releases\/2023\/american-diabetes-association-highlights-novel-agent-retatrutide-results-substantial-weight-reduction-people-with-obesity-type-2-diabetes-during-late-breaking-symposium<\/li>\n\n\n\n<li>Jastreboff AM, Kaplan LM, Fr\u00edas JP, Wu Q, Du Y, Gurbuz S, Coskun T, Haupt A, Milicevic Z, Hartman ML; Retatrutide Phase 2 Obesity Trial Investigators. Triple-Hormone-Receptor Agonist Retatrutide for Obesity &#8211; A Phase 2 Trial.&nbsp;<em>N Engl J Med<\/em>. 2023 Jun 26. doi: 10.1056\/NEJMoa2301972.<\/li>\n\n\n\n<li>Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S, Thomas MK, Hartman ML, Haupt A, Milicevic Z, Coskun T. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.&nbsp;<em>Lancet<\/em>. 2023 Jun 26:S0140-6736(23)01053-X. doi: 10.1016\/S0140-6736(23)01053-X.<\/li>\n\n\n\n<li>Mitchel L. Zoler. Triple Agonist Retatrutide Hits New Weight-Loss Highs. Medscape. Updated 26 Jun 2023. Accessed date 06 Jun 2023. URL: https:\/\/www.medscape.com\/viewarticle\/993714<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>M\u1ede \u0110\u1ea6U T\u1eeb ng\u00e0y 23 \u2013 26 th\u00e1ng 06 v\u1eeba qua, H\u1ed9i ngh\u1ecb Khoa h\u1ecdc Th\u01b0\u1eddng ni\u00ean l\u1ea7n th\u1ee9 83 c\u1ee7a Hi\u1ec7p h\u1ed9i \u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng Hoa K\u1ef3 (ADA) \u0111\u00e3 di\u1ec5n ra t\u1ea1i San Diego. H\u1ed9i ngh\u1ecb \u0111\u00e3 mang \u0111\u1ebfn nhi\u1ec1u th\u00f4ng tin v\u00e0 b\u1eb1ng ch\u1ee9ng y khoa m\u1edbi trong ki\u1ec3m so\u00e1t b\u1ec7nh nh\u00e2n \u0111\u00e1i &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/docquity.com\/vi\/articles\/hoi-nghi-ada-2023-retatrutide-giam-duoc-muc-can-nang-ky-luc\/\"> <span class=\"screen-reader-text\">H\u1ed9i ngh\u1ecb ADA 2023: Retatrutide gi\u1ea3m \u0111\u01b0\u1ee3c m\u1ee9c c\u00e2n n\u1eb7ng k\u1ef7 l\u1ee5c<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":123,"featured_media":10835,"comment_status":"closed","ping_status":"closed","template":"","meta":{"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"articles_categories":[1370],"articles_tags":[],"articles_topics":[1437],"articles_languages":[1375],"articles_filters":[],"class_list":["post-10834","articles","type-articles","status-publish","has-post-thumbnail","hentry","articles_categories-medical-content-vi","articles_languages-vietnamese-vi"],"_links":{"self":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/10834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles"}],"about":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/types\/articles"}],"author":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/comments?post=10834"}],"version-history":[{"count":0,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/10834\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media\/10835"}],"wp:attachment":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media?parent=10834"}],"wp:term":[{"taxonomy":"articles_categories","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_categories?post=10834"},{"taxonomy":"articles_tags","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_tags?post=10834"},{"taxonomy":"articles_topics","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_topics?post=10834"},{"taxonomy":"articles_languages","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_languages?post=10834"},{"taxonomy":"articles_filters","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_filters?post=10834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}