{"id":10829,"date":"2023-08-02T23:51:35","date_gmt":"2023-08-02T15:51:35","guid":{"rendered":"https:\/\/docquity.com\/?post_type=articles&#038;p=10829"},"modified":"2025-02-11T13:36:20","modified_gmt":"2025-02-11T05:36:20","slug":"sotagliflozin-them-mot-tac-nhan-moi-thuoc-nhom-sglt-2-duoc-fda-chap-thuan-cho-chi-dinh-suy-tim","status":"publish","type":"articles","link":"https:\/\/docquity.com\/vi\/articles\/sotagliflozin-them-mot-tac-nhan-moi-thuoc-nhom-sglt-2-duoc-fda-chap-thuan-cho-chi-dinh-suy-tim\/","title":{"rendered":"SOTAGLIFLOZIN: Th\u00eam m\u1ed9t t\u00e1c nh\u00e2n m\u1edbi thu\u1ed9c nh\u00f3m SGLT-2 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn cho ch\u1ec9 \u0111\u1ecbnh suy tim"},"content":{"rendered":"\n<p><strong>M\u1ede \u0110\u1ea6U<\/strong><\/p>\n\n\n\n<p>V\u00e0o ng\u00e0y 26 th\u00e1ng N\u0103m, n\u0103m 2023, C\u1ee5c Ki\u1ec3m so\u00e1t Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (U.S. Food and Drug Administration \u2013 FDA) \u0111\u00e3 ch\u1ea5p thu\u1eadn sotagliflozin c\u1ee7a c\u00f4ng ty Lexicon cho ch\u1ec9 \u0111\u1ecbnh gi\u1ea3m nguy c\u01a1 t\u1eed vong do tim m\u1ea1ch, nh\u1eadp vi\u1ec7n do suy tim v\u00e0 th\u0103m kh\u00e1m c\u1ea5p c\u1ee9u do suy tim \u1edf b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh m\u1eafc:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Suy tim ho\u1eb7c<\/li>\n\n\n\n<li>\u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2, suy th\u1eadn v\u00e0 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 tim m\u1ea1ch kh\u00e1c<\/li>\n<\/ul>\n\n\n\n<p>Ch\u1ec9 \u0111\u1ecbnh bao g\u1ed3m c\u1ea3 b\u1ec7nh nh\u00e2n suy tim v\u1edbi ph\u00e2n su\u1ea5t t\u1ed1ng m\u00e1u th\u1ea5t tr\u00e1i b\u1ea3o t\u1ed3m ho\u1eb7c ph\u00e2n su\u1ea5t t\u1ed1ng m\u00e1u th\u1ea5t tr\u00e1i gi\u1ea3m \u1edf b\u1ec7nh nh\u00e2n m\u1eafc ho\u1eb7c kh\u00f4ng m\u1eafc k\u00e8m \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2.<\/p>\n\n\n\n<p><strong>C\u01a0 S\u1ede KHOA H\u1eccC<\/strong><\/p>\n\n\n\n<p>Ch\u1ea5p thu\u1eadn \u0111\u01b0\u1ee3c \u0111\u01b0a ra d\u1ef1a tr\u00ean k\u1ebft c\u1ee5c c\u1ee7a c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha 3, ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c nh\u1eb1m \u0111\u00e1nh gi\u00e1 k\u1ebft c\u1ee5c tim m\u1ea1ch \u1edf b\u1ec7nh nh\u00e2n suy tim ho\u1eb7c c\u00f3 nguy c\u01a1 m\u1eafc suy tim \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng sotagliflozin. C\u00e1c th\u1eed nghi\u1ec7m n\u00e0y bao g\u1ed3m SOLOIST \u2013 WHF v\u00e0 SCORED. Hai th\u1eed nghi\u1ec7m n\u00e0y bao g\u1ed3m t\u1ed5ng c\u1ed9ng kho\u1ea3ng 12000 b\u1ec7nh nh\u00e2n.<\/p>\n\n\n\n<p><strong><em>Nghi\u00ean c\u1ee9u SLOIST \u2013 WHF<\/em><\/strong><\/p>\n\n\n\n<p>SOLOIST \u2013 WHF l\u00e0 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha 3, \u0111a trung t\u00e2m, ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c c\u1ee7a sotagliflozin tr\u00ean tim m\u1ea1ch so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c khi \u0111\u01b0\u1ee3c b\u1ed5 sung v\u00e0o ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb ti\u00eau chu\u1ea9n \u1edf 1222 b\u1ec7nh nh\u00e2n m\u1eafc \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 v\u1eeba m\u1edbi nh\u1eadp vi\u1ec7n do suy tim tr\u1edf n\u1eb7ng. Ti\u00eau ch\u00ednh \u0111\u00e1nh gi\u00e1 ch\u00ednh l\u00e0 t\u1ed5ng s\u1ed1 bi\u1ebfn c\u1ed1 bao g\u1ed3m t\u1eed vong do nguy\u00ean nh\u00e2n tim m\u1ea1ch, nh\u1eadp vi\u1ec7n do suy tim v\u00e0 kh\u00e1m c\u1ea5p c\u1ee9u do suy tim. K\u1ebft qu\u1ea3 c\u1ee7a th\u1eed nghi\u1ec7m SOLOIST \u2013 WHF cho th\u1ea5y sotagliflozin l\u00e0m gi\u1ea3m c\u00f3 \u00fd ngh\u0129a nguy c\u01a1 g\u1eb7p c\u00e1c bi\u1ebfn c\u1ed1 g\u1ed9p nh\u1eadp vi\u1ec7n do suy tim, kh\u00e1m c\u1ea5p c\u1ee9u do suy tim v\u00e0 t\u1eed vong do tim m\u1ea1ch kho\u1ea3ng 33% so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c \u1edf b\u1ec7nh nh\u00e2n v\u1eeba m\u1edbi nh\u1eadp vi\u1ec7n do suy tim tr\u1edf n\u1eb7ng.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/s3-ap-southeast-1.amazonaws.com\/bucket.docquity.com\/journals\/editor\/file-b07465f14c30e073e45a0f03cbf28834.png\" alt=\"\" \/><\/figure>\n\n\n\n<p><strong><em>Nghi\u00ean c\u1ee9u SCORED<\/em><\/strong><\/p>\n\n\n\n<p>SCORED l\u00e0 th\u1eed nghi\u00eam l\u00e2m s\u00e0ng pha 3, \u0111a trung t\u00e2m, ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i, \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 hi\u1ec7u l\u1ef1c c\u1ee7a sotagliflozin so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c khi b\u1ed5 sung v\u00e0o ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb ti\u00eau chu\u1ea9n \u1edf 10584 b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 1, b\u1ec7nh th\u1eadn m\u1ea1n v\u1edbi GFR &lt; 60 mL\/ph\u00fat\/1.73 m<sup>2<\/sup>&nbsp;v\u00e0 c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh tim m\u1ea1ch. Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ch\u00ednh l\u00e0 t\u1ed5ng s\u1ed1 bi\u1ebfn c\u1ed1 bao g\u1ed3m t\u1eed vong do nguy\u00ean nh\u00e2n tim m\u1ea1ch, nh\u1eadp vi\u1ec7n do suy tim v\u00e0 kh\u00e1m c\u1ea5p c\u1ee9u do suy tim. Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ph\u1ee5 bao g\u1ed3m t\u1ed5ng s\u1ed1 bi\u1ebfn c\u1ed1 t\u1eed vong do nguy\u00ean nh\u00e2n tim m\u1ea1ch, nh\u1ed3i m\u00e1u c\u01a1 tim kh\u00f4ng d\u1eabn \u0111\u1ebfn t\u1eed vong v\u00e0 \u0111\u1ed9t qu\u1ef5 kh\u00f4ng d\u1eabn \u0111\u1ebfn t\u1eed vong. K\u1ebft qu\u1ea3 c\u1ee7a th\u1eed nghi\u1ec7m SCORED cho th\u1ea5y sotagliflozin c\u00f3 th\u1ec3 gi\u1ea3m t\u1ef7 l\u1ec7 t\u1eed vong do nguy\u00ean nh\u00e2n tim m\u1ea1ch, nh\u1eadp vi\u1ec7n do suy tim v\u00e0 th\u0103m kh\u00e1m c\u1ea5p c\u1ee9u do suy tim kho\u1ea3ng 26% so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n\n\n\n<p><strong>SOTAGLIFLOZIN<\/strong><\/p>\n\n\n\n<p>Sotagliflozin l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf c\u1ea3 k\u00eanh \u0111\u1ed3ng v\u1eadn chuy\u1ec3n natri \u2013 glucose type 2 (sodium-glucose co-transporter type 2inhibitor \u2013 SGLT-2i) v\u00e0 type 1 (SGLT1i). Thu\u1ed1c \u1ee9c ch\u1ebf SGLT \u0111\u01b0\u1ee3c Hi\u1ec7p h\u1ed9i Tim m\u1ea1ch Hoa K\u1ef3 (American Heart Association \u2013 AHA), Vi\u1ec7n Tim m\u1ea1ch Hoa K\u1ef3 (American College of Cardiology \u2013 ACC) v\u00e0 Hi\u1ec7p h\u1ed9i Suy tim Hoa K\u1ef3 (Heart Failure Society of America \u2013 HFSA) trong h\u01b0\u1edbng d\u1eabn ki\u1ec3m so\u00e1t suy tim \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 n\u0103m 2023. ACC c\u0169ng nh\u1ea5n m\u1ea1nh l\u1ee3i \u00edch c\u1ee7a ch\u1ea5t \u1ee9c ch\u1ebf SGLT trong ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb theo h\u01b0\u1edbng d\u1eabn \u1edf b\u1ec7nh nh\u00e2n suy tim ph\u00e2n su\u1ea5t t\u1ed1ng m\u00e1u b\u1ea3o t\u1ed3n. D\u1ef1a theo khuy\u1ebfn c\u00e1o c\u1ee7a ACC, ch\u1ea5t \u1ee9c ch\u1ebf SGLT2 n\u00ean \u0111\u01b0\u1ee3c kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb \u1edf t\u1ea5t c\u1ea3 b\u1ec7nh nh\u00e2n suy tim ph\u00e2n su\u1ea5t t\u1ed1ng m\u00e1u b\u1ea3o t\u1ed3n c\u00f3 t\u00ecnh tr\u1ea1ng b\u1ec7nh \u1ed5n \u0111\u1ecbnh khi \u0111i\u1ec1u tr\u1ecb n\u1ed9i tr\u00fa v\u00e0 kh\u00f4ng b\u1ecb ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh.<\/p>\n\n\n\n<p><strong><em>Ch\u1ec9 \u0111\u1ecbnh<\/em><\/strong><\/p>\n\n\n\n<p>Sotagliflozin \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 t\u1eed vong do tim m\u1ea1ch, nh\u1eadp vi\u1ec7n do suy tim v\u00e0 kh\u00e1m c\u1ea5p c\u1ee9u do suy tim \u1edf b\u1ec7nh nh\u00e2n:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Suy tim ho\u1eb7c<\/li>\n\n\n\n<li>\u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2, b\u1ec7nh th\u1eadn m\u1ea1n v\u00e0 c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 tim m\u1ea1ch kh\u00e1c<\/li>\n<\/ul>\n\n\n\n<p><strong><em>Li\u1ec1u<\/em><\/strong><\/p>\n\n\n\n<p>\u0110\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn, volume status v\u00e0 \u0111i\u1ec1u ch\u1ec9nh th\u1ec3 t\u00edch suy gi\u1ea3m tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng sotagliflozin n\u1ebfu c\u1ea7n thi\u1ebft. Sotagliflozin cho b\u1ec7nh nh\u00e2n suy tim m\u1ea5t b\u00f9 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c kh\u1edfi \u0111\u1ea7u n\u1ebfu b\u1ec7nh nh\u00e2n \u1ed5n \u0111\u1ecbnh huy\u1ebft \u0111\u1ed9ng.<\/p>\n\n\n\n<p><strong><em>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/em><\/strong><\/p>\n\n\n\n<p>Sotagliflozin \u0111\u01b0\u1ee3c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho b\u1ec7nh nh\u00e2n nh\u1ea1y c\u1ea3m v\u1edbi sotagliflozin ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c<\/p>\n\n\n\n<p><strong><em>Nhi\u1ec5m toan keton<\/em><\/strong><\/p>\n\n\n\n<p>Sotagliflozin l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m toan keton \u1edf b\u1ec7nh nh\u00e2n m\u1eafc \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 1. B\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 v\u00e0 r\u1ed1i lo\u1ea1n tuy\u1ebfn t\u1ee5y c\u0169ng c\u00f3 nguy c\u01a1 n\u00e0y. Nguy c\u01a1 nhi\u1ec5m toan keton c\u00f3 th\u1ec3 t\u0103ng v\u1edbi li\u1ec1u cao h\u01a1n. Tuy nhi\u00ean, c\u00e1c ch\u1ea5t SGLT2i c\u0169ng \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o h\u1eadu m\u00e3i v\u1ec1 c\u00e1c bi\u1ebfn c\u1ed1 nhi\u1ec5m toan keton d\u1eabn \u0111\u1ebfn t\u1ef7 vong \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2. Tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng sotagliflozin, b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 y\u1ebfu t\u1ed1 nguy c\u01a1 nhi\u1ec5m toan keton. C\u00e2n nh\u1eafc gi\u00e1m s\u00e1t keton \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 1 v\u00e0 c\u00e2 nh\u1eafc gi\u00e1m s\u00e1t keton \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 kh\u00e1c, \u0111\u1ed3ng th\u1eddi gi\u00e1o d\u1ee5c b\u1ec7nh nh\u00e2n v\u1ec1 nh\u1eefng bi\u1ec3u hi\u1ec7n\/tri\u1ec7u ch\u1ee9ng c\u1ee7a nhi\u1ec5m toan keton. B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng sotagliflozin c\u00f3 th\u1ec3 c\u1ea7n ph\u1ea3i ng\u01b0ng \u0111i\u1ec1u tr\u1ecb gi\u00e1n \u0111o\u1ea1n n\u1ebfu t\u00ecnh tr\u1ea1ng l\u00e2m s\u00e0ng c\u00f3 th\u1ec3 ti\u00ean \u0111o\u00e1n \u0111\u01b0\u1ee3c t\u00ecnh tr\u1ea1ng nhi\u1ec5m toan keton. Sotagliflozin kh\u00f4ng c\u00f3 ch\u1ec9 \u0111\u1ecbnh cho ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft.<\/p>\n\n\n\n<p><strong><em>Thi\u1ebfu h\u1ee5t th\u1ec3 t\u00edch<\/em><\/strong><\/p>\n\n\n\n<p>Sotagliflozin c\u00f3 th\u1ec3 g\u00e2y ra thi\u1ebfu h\u1ee5t th\u1ec3 t\u00edch n\u1ed9i m\u1ea1ch, t\u1eeb \u0111\u00f3 d\u1eabn \u0111\u1ebfn h\u1ea1 huy\u1ebft \u00e1p c\u00f3 bi\u1ec3u hi\u1ec7n tri\u1ec7u ch\u1ee9ng ho\u1eb7c thay \u0111\u1ed5i creatinin c\u1ea5p tho\u00e1ng qua. \u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o h\u1eadu m\u00e3i cho th\u1ea5y SGTL2i c\u00f3 th\u1ec3 g\u00e2y suy th\u1eadn c\u1ea5p \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2, m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u1ea7n ph\u1ea3i nh\u1eadp vi\u1ec7n v\u00e0 l\u1ecdc th\u1eadn. B\u1ec7nh nh\u00e2n c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn suy gi\u1ea3m (GFR &lt; 60 mL\/ph\u00fat\/1.73 m<sup>2<\/sup>), b\u1ec7nh nh\u00e2n cao tu\u1ed5i ho\u1eb7c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c l\u1ee3i ti\u1ec3u quai c\u00f3 th\u1ec3 c\u00f3 nguy c\u01a1 b\u1ecb thi\u1ebfu h\u1ee5t th\u1ec3 t\u00edch ho\u1eb7c h\u1ea1 huy\u1ebft \u00e1p t\u0103ng. Tr\u01b0\u1edbc khi kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng sotagliflozin \u1edf b\u1ec7nh nh\u00e2n c\u00f3 \u2265 1 \u0111\u1eb7c \u0111i\u1ec3m n\u00f3i tr\u00ean, \u0111\u00e1nh gi\u00e1 th\u1ec3 t\u00edch v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u, tri\u1ec7u ch\u1ee9ng h\u1ea1 huy\u1ebft \u00e1p trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n\n\n<p><strong><em>Nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u v\u00e0 vi\u00eam b\u1ec3 th\u1eadn<\/em><\/strong><\/p>\n\n\n\n<p>\u0110i\u1ec1u tr\u1ecb v\u1edbi SGLT2i (bao g\u1ed3m c\u1ea3 sotagliflozin) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u. Nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u nghi\u00eam tr\u1ecdng bao g\u1ed3m urosepsis v\u00e0 vi\u00eam b\u1ec3 th\u1eadn c\u1ea7n ph\u1ea3i nh\u1eadp vi\u1ec7n \u0111i\u1ec1u tr\u1ecb c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng SGLT2i. \u0110\u00e1nh gi\u00e1 nh\u1eefng tri\u1ec7u ch\u1ee9ng\/bi\u1ec3u hi\u1ec7n c\u1ee7a nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u v\u00e0 \u0111i\u1ec1u tr\u1ecb nhanh ch\u00f3ng.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p><strong>T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>LEXICON ANNOUNCES FDA APPROVAL OF INPEFA\u2122 (SOTAGLIFLOZIN) FOR TREATMENT OF HEART FAILURE. Updated 30 May 2023. Accessed date 29 May 2023. URL: https:\/\/www.lexpharma.com\/media-center\/news\/2023-05-26-lexicon-announces-fda-approval-of-inpefa-sotagliflozin-for-treatment-of-heart-failure<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>M\u1ede \u0110\u1ea6U V\u00e0o ng\u00e0y 26 th\u00e1ng N\u0103m, n\u0103m 2023, C\u1ee5c Ki\u1ec3m so\u00e1t Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (U.S. Food and Drug Administration \u2013 FDA) \u0111\u00e3 ch\u1ea5p thu\u1eadn sotagliflozin c\u1ee7a c\u00f4ng ty Lexicon cho ch\u1ec9 \u0111\u1ecbnh gi\u1ea3m nguy c\u01a1 t\u1eed vong do tim m\u1ea1ch, nh\u1eadp vi\u1ec7n do suy tim v\u00e0 th\u0103m kh\u00e1m c\u1ea5p c\u1ee9u &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/docquity.com\/vi\/articles\/sotagliflozin-them-mot-tac-nhan-moi-thuoc-nhom-sglt-2-duoc-fda-chap-thuan-cho-chi-dinh-suy-tim\/\"> <span class=\"screen-reader-text\">SOTAGLIFLOZIN: Th\u00eam m\u1ed9t t\u00e1c nh\u00e2n m\u1edbi thu\u1ed9c nh\u00f3m SGLT-2 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn cho ch\u1ec9 \u0111\u1ecbnh suy tim<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":123,"featured_media":10830,"comment_status":"closed","ping_status":"closed","template":"","meta":{"content-type":"","inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"articles_categories":[1370],"articles_tags":[],"articles_topics":[1439],"articles_languages":[1375],"articles_filters":[],"class_list":["post-10829","articles","type-articles","status-publish","has-post-thumbnail","hentry","articles_categories-medical-content-vi","articles_languages-vietnamese-vi"],"_links":{"self":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/10829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles"}],"about":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/types\/articles"}],"author":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/comments?post=10829"}],"version-history":[{"count":0,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles\/10829\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media\/10830"}],"wp:attachment":[{"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/media?parent=10829"}],"wp:term":[{"taxonomy":"articles_categories","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_categories?post=10829"},{"taxonomy":"articles_tags","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_tags?post=10829"},{"taxonomy":"articles_topics","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_topics?post=10829"},{"taxonomy":"articles_languages","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_languages?post=10829"},{"taxonomy":"articles_filters","embeddable":true,"href":"https:\/\/docquity.com\/vi\/wp-json\/wp\/v2\/articles_filters?post=10829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}